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The Miami Framework...
The Miami Framework for ALS and related neurodegenerative disorders : an integrated view of phenotype and biology
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- Benatar, Michael (författare)
- Department of Neurology, Miller School of Medicine, University of Miami, FL, Miami, United States
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- Wuu, Joanne (författare)
- Department of Neurology, Miller School of Medicine, University of Miami, FL, Miami, United States
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- Huey, Edward D. (författare)
- Department of Psychiatry and Human Behaviour, Alpert Medical School of Brown University, RI, Providence, United States
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- McMillan, Corey T. (författare)
- Department of Neurology, University of Pennsylvania Perelman School of Medicine, PA, Philadelphia, United States
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- Petersen, Ronald C. (författare)
- Department of Neurology, Mayo Clinic, MN, Rochester, United States
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- Postuma, Ronald (författare)
- Department of Neurology, Montreal Neurological Institute, McGill University, QC, Montreal, Canada
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- McHutchison, Caroline (författare)
- Human Cognitive Neuroscience, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, United Kingdom
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- Dratch, Laynie (författare)
- Department of Neurology, University of Pennsylvania Perelman School of Medicine, PA, Philadelphia, United States
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- Arias, Jalayne J. (författare)
- Department of Health Policy & Behavioral Sciences, School of Public Health, Georgia State University, GA, Atlanta, United States
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- Crawley, Anita (författare)
- NY, Buffalo, United States
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- Houlden, Henry (författare)
- UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, United Kingdom
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- McDermott, Michael P. (författare)
- Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, NY, Rochester, United States; Department of Neurology, University of Rochester School of Medicine and Dentistry, NY, Rochester, United States
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- Cai, Xueya (författare)
- Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, NY, Rochester, United States
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- Thakur, Neil (författare)
- ALS Association, VA, Arlington, United States
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- Boxer, Adam (författare)
- Department of Neurology, University of California, CA, San Francisco, United States
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- Rosen, Howard (författare)
- Department of Neurology, University of California, CA, San Francisco, United States
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- Boeve, Bradley F. (författare)
- Department of Neurology, Mayo Clinic, MN, Rochester, United States
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- Dacks, Penny (författare)
- Association for Frontotemporal Degeneration, PA, King of Prussia, United States
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- Cosentino, Stephanie (författare)
- Department of Psychiatry, Columbia University, New York, NY, USA
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- Abrahams, Sharon (författare)
- Human Cognitive Neuroscience, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, United Kingdom
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- Shneider, Neil (författare)
- Department of Neurology, Columbia University, New York, NY, USA
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- Lingor, Paul (författare)
- Department of Neurology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany
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- Shefner, Jeremy (författare)
- Department of Neurology, Barrow Neurological Institute, AZ, Phoenix, United States
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- Andersen, Peter M., 1962- (författare)
- Umeå universitet,Neurovetenskaper
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- Al-Chalabi, Ammar (författare)
- Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, United Kingdom; Department of Neurology, King's College Hospital, London, United Kingdom
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- Turner, Martin R. (författare)
- Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- Engelska.
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Ingår i: Nature Reviews Neurology. - : Springer Nature. - 1759-4758 .- 1759-4766. ; 20:6, s. 364-376
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence for a pre-symptomatic stage of disease and observations that this stage of disease might not always be clinically silent, is challenging traditional views of these disorders. These advances have highlighted the need to adapt ingrained notions of these clinical syndromes to include both the full phenotypic continuum - from clinically silent, to prodromal, to clinically manifest - and the expanded phenotypic spectrum that includes ALS, frontotemporal dementia and some movement disorders. The updated clinical paradigms should also align with our understanding of the biology of these disorders, reflected in measurable biomarkers. The Miami Framework, emerging from discussions at the Second International Pre-Symptomatic ALS Workshop in Miami (February 2023; a full list of attendees and their affiliations appears in the Supplementary Information) proposes a classification system built on: first, three parallel phenotypic axes - motor neuron, frontotemporal and extrapyramidal - rather than the unitary approach of combining all phenotypic elements into a single clinical entity; and second, biomarkers that reflect different aspects of the underlying pathology and biology of neurodegeneration. This framework decouples clinical syndromes from biomarker evidence of disease and builds on experiences from other neurodegenerative diseases to offer a unified approach to specifying the pleiotropic clinical manifestations of disease and describing the trajectory of emergent biomarkers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Benatar, Michael
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Wuu, Joanne
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Huey, Edward D.
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McMillan, Corey ...
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Petersen, Ronald ...
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Postuma, Ronald
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McHutchison, Car ...
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Dratch, Laynie
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Arias, Jalayne J ...
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Crawley, Anita
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Houlden, Henry
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McDermott, Micha ...
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Cai, Xueya
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Thakur, Neil
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Boxer, Adam
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Rosen, Howard
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Boeve, Bradley F ...
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Dacks, Penny
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Cosentino, Steph ...
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Abrahams, Sharon
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Shneider, Neil
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Lingor, Paul
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Shefner, Jeremy
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Andersen, Peter ...
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Al-Chalabi, Amma ...
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Turner, Martin R ...
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