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Sökning: WFRF:(Crawley J) > (2020-2024) > The Miami Framework...

  • Benatar, MichaelDepartment of Neurology, Miller School of Medicine, University of Miami, FL, Miami, United States (författare)

The Miami Framework for ALS and related neurodegenerative disorders : an integrated view of phenotype and biology

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Springer Nature,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-226161
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-226161URI
  • https://doi.org/10.1038/s41582-024-00961-zDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Erratum:  Benatar, M., Wuu, J., Huey, E.D. et al. The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology. Nat Rev Neurol 20 (6), 377 (2024). https://doi.org/10.1038/s41582-024-00961-z
  • Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence for a pre-symptomatic stage of disease and observations that this stage of disease might not always be clinically silent, is challenging traditional views of these disorders. These advances have highlighted the need to adapt ingrained notions of these clinical syndromes to include both the full phenotypic continuum - from clinically silent, to prodromal, to clinically manifest - and the expanded phenotypic spectrum that includes ALS, frontotemporal dementia and some movement disorders. The updated clinical paradigms should also align with our understanding of the biology of these disorders, reflected in measurable biomarkers. The Miami Framework, emerging from discussions at the Second International Pre-Symptomatic ALS Workshop in Miami (February 2023; a full list of attendees and their affiliations appears in the Supplementary Information) proposes a classification system built on: first, three parallel phenotypic axes - motor neuron, frontotemporal and extrapyramidal - rather than the unitary approach of combining all phenotypic elements into a single clinical entity; and second, biomarkers that reflect different aspects of the underlying pathology and biology of neurodegeneration. This framework decouples clinical syndromes from biomarker evidence of disease and builds on experiences from other neurodegenerative diseases to offer a unified approach to specifying the pleiotropic clinical manifestations of disease and describing the trajectory of emergent biomarkers.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wuu, JoanneDepartment of Neurology, Miller School of Medicine, University of Miami, FL, Miami, United States (författare)
  • Huey, Edward D.Department of Psychiatry and Human Behaviour, Alpert Medical School of Brown University, RI, Providence, United States (författare)
  • McMillan, Corey T.Department of Neurology, University of Pennsylvania Perelman School of Medicine, PA, Philadelphia, United States (författare)
  • Petersen, Ronald C.Department of Neurology, Mayo Clinic, MN, Rochester, United States (författare)
  • Postuma, RonaldDepartment of Neurology, Montreal Neurological Institute, McGill University, QC, Montreal, Canada (författare)
  • McHutchison, CarolineHuman Cognitive Neuroscience, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Dratch, LaynieDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, PA, Philadelphia, United States (författare)
  • Arias, Jalayne J.Department of Health Policy & Behavioral Sciences, School of Public Health, Georgia State University, GA, Atlanta, United States (författare)
  • Crawley, AnitaNY, Buffalo, United States (författare)
  • Houlden, HenryUCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, United Kingdom (författare)
  • McDermott, Michael P.Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, NY, Rochester, United States; Department of Neurology, University of Rochester School of Medicine and Dentistry, NY, Rochester, United States (författare)
  • Cai, XueyaDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, NY, Rochester, United States (författare)
  • Thakur, NeilALS Association, VA, Arlington, United States (författare)
  • Boxer, AdamDepartment of Neurology, University of California, CA, San Francisco, United States (författare)
  • Rosen, HowardDepartment of Neurology, University of California, CA, San Francisco, United States (författare)
  • Boeve, Bradley F.Department of Neurology, Mayo Clinic, MN, Rochester, United States (författare)
  • Dacks, PennyAssociation for Frontotemporal Degeneration, PA, King of Prussia, United States (författare)
  • Cosentino, StephanieDepartment of Psychiatry, Columbia University, New York, NY, USA (författare)
  • Abrahams, SharonHuman Cognitive Neuroscience, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, United Kingdom (författare)
  • Shneider, NeilDepartment of Neurology, Columbia University, New York, NY, USA (författare)
  • Lingor, PaulDepartment of Neurology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany (författare)
  • Shefner, JeremyDepartment of Neurology, Barrow Neurological Institute, AZ, Phoenix, United States (författare)
  • Andersen, Peter M.,1962-Umeå universitet,Neurovetenskaper(Swepub:umu)pean0001 (författare)
  • Al-Chalabi, AmmarDepartment of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, United Kingdom; Department of Neurology, King's College Hospital, London, United Kingdom (författare)
  • Turner, Martin R.Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom (författare)
  • Department of Neurology, Miller School of Medicine, University of Miami, FL, Miami, United StatesDepartment of Psychiatry and Human Behaviour, Alpert Medical School of Brown University, RI, Providence, United States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Reviews Neurology: Springer Nature20:6, s. 364-3761759-47581759-4766

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