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Acromegaly manageme...
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Arlien-Søborg, Mai C.Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
(author)
Acromegaly management in the nordic countries : a Delphi consensus survey
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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2024
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John Wiley & Sons,2024
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-226954
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-226954URI
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https://doi.org/10.1111/cen.15095DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-205153URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Pfizer
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Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.Methods: A Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1−7). Consensus was defined as ≥80% of panelists rating their agreement as ≥5 or ≤3 on the Likert-type scale.Results: Consensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.Conclusion: This consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Dal, JakobDepartment of Endocrinology, Aalborg University Hospital, Aarhus, Denmark; Steno Diabetes Center North Jutland, Aalborg, Denmark,Aalborg Univ Hosp, Denmark; Steno Diabet Ctr North Jutland, Denmark
(author)
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Heck, AnsgarOslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway
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Stochholm, KirstineDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
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Husted, EigilDepartment of Endocrinology, Aalborg University Hospital, Aarhus, Denmark,Aalborg Univ Hosp, Denmark
(author)
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Feltoft, Claus LarsenCopenhagen University Hospital—Herlev and Gentofte, Kobenhavn, Denmark,Copenhagen Univ Hosp Herlev & Gentofte, Denmark
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Rasmussen, Åse KroghCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
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Feldt-Rasmussen, UllaCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
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Andreassen, MikkelCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
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Klose, Marianne ChristinaCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
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Nielsen, Torben LeoOdense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
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Andersen, Marianne SkovsagerOdense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
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Christensen, Louise LehmannOdense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
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Krogh, JesperCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
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Jarlov, AnneCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
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Bollerslev, JensOslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway
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Nermoen, IngridAkershus University Hospital, lørenskog, Norway,Akershus Univ Hosp, Norway
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Oksnes, MarianneHaukeland University Hospital, Bergen, Norway,Haukeland Hosp, Norway
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Dahlqvist, PerUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden,Umea Univ, Sweden; Norrlands Univ Hosp, Sweden(Swepub:umu)perdat96
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Olsson, TommyUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden,Umea Univ, Sweden; Norrlands Univ Hosp, Sweden(Swepub:umu)tool0003
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Berinder, KatarinaKarolinska University Hospital, Sweden,Karolinska Univ Hosp, Sweden
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Hoybye, CharlotteKarolinska University Hospital, Sweden,Karolinska Univ Hosp, Sweden
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Petersson, MariaKarolinska University Hospital, Sweden,Karolinska Univ Hosp, Sweden
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Akerman, Anna-karinSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, Sweden; Department of Medicine, Örebro University Hospital, Örebro, Sweden,Orebro Univ, Sweden
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Wahlberg, JeanetteDepartment of Medicine, Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Sweden
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Ekman, BertilLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN,Region Östergötland, Endokrinmedicinska kliniken,Department of Endocrinology and the Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden(Swepub:liu)berek83
(author)
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Engstrom, Britt EdenUppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden
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Johannsson, GudmundurDepartment of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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Ragnarsson, OskarDepartment of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Sweden
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Olsson, DanielDepartment of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden; Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; AstraZeneca, Sweden
(author)
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Sigurjónsdóttir, Helga ÁgústaThe National University Hospital of Iceland, Gothenburg, Iceland; School of Medicine, University of Iceland, Reykjavik, Iceland,Natl Univ Hosp Iceland, Iceland; Univ Iceland, Iceland
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Fougner, Stine LyngviDepartment of Endocrinology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway,Trondheim Reg & Univ Hosp, Norway; Norwegian Univ Sci & Technol NTNU, Norway
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Matikainen, NiinaHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
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Vehkavaara, SatuHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
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Metso, SaaraTampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland
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Jaatinen, PiaTampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland
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Hämäläinen, PäiviTampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland
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Rintamäki, ReetaKuopio University Hospital, Kuopio, Finland,Kuopio Univ Hosp, Finland
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Yliaska, IinaOulu University Hospital, Oulu, Finland,Oulu Univ Hosp, Finland
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Immonen, HeidiTurku University Hospital, Turku, Finland,Turku Univ Hosp, Finland
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Mäkimattila, SariHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
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Cederberg-Tamminen, HennaHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
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Viukari, MariannaHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
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Nevalainen, PasiTampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland
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Nuutila, PirjoTurku University Hospital, Turku, Finland,Turku Univ Hosp, Finland
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Schalin-Jäntti, CamillaHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
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Burman, PiaSkåne University Hospital, Lund University, Malmö, Sweden,Lund Univ, Sweden
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Jørgensen, Jens Otto LundeDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
(author)
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, DenmarkAarhus Univ Hosp, Denmark
(creator_code:org_t)
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In:Clinical Endocrinology: John Wiley & Sons0300-06641365-2265
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Arlien-Søborg, M ...
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Dal, Jakob
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Heck, Ansgar
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Stochholm, Kirst ...
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Husted, Eigil
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Feltoft, Claus L ...
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Rasmussen, Åse K ...
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Feldt-Rasmussen, ...
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Andreassen, Mikk ...
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Klose, Marianne ...
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Nielsen, Torben ...
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Andersen, Marian ...
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Christensen, Lou ...
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Krogh, Jesper
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Jarlov, Anne
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Bollerslev, Jens
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Nermoen, Ingrid
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Oksnes, Marianne
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Dahlqvist, Per
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Olsson, Tommy
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Berinder, Katari ...
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Hoybye, Charlott ...
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Petersson, Maria
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Akerman, Anna-ka ...
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Wahlberg, Jeanet ...
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Ekman, Bertil
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Engstrom, Britt ...
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Johannsson, Gudm ...
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Ragnarsson, Oska ...
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Olsson, Daniel
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Sigurjónsdóttir, ...
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Fougner, Stine L ...
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Matikainen, Niin ...
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Vehkavaara, Satu
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Metso, Saara
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Jaatinen, Pia
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Hämäläinen, Päiv ...
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Rintamäki, Reeta
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Yliaska, Iina
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Immonen, Heidi
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Mäkimattila, Sar ...
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Cederberg-Tammin ...
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Viukari, Mariann ...
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Nevalainen, Pasi
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Nuutila, Pirjo
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Schalin-Jäntti, ...
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Umeå University
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Linköping University