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  • Arlien-Søborg, Mai C.Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark (author)

Acromegaly management in the nordic countries : a Delphi consensus survey

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024
  • John Wiley & Sons,2024
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-226954
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-226954URI
  • https://doi.org/10.1111/cen.15095DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-205153URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Pfizer
  • Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.Methods: A Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1−7). Consensus was defined as ≥80% of panelists rating their agreement as ≥5 or ≤3 on the Likert-type scale.Results: Consensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.Conclusion: This consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.

Subject headings and genre

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  • Dal, JakobDepartment of Endocrinology, Aalborg University Hospital, Aarhus, Denmark; Steno Diabetes Center North Jutland, Aalborg, Denmark,Aalborg Univ Hosp, Denmark; Steno Diabet Ctr North Jutland, Denmark (author)
  • Heck, AnsgarOslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway (author)
  • Stochholm, KirstineDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark (author)
  • Husted, EigilDepartment of Endocrinology, Aalborg University Hospital, Aarhus, Denmark,Aalborg Univ Hosp, Denmark (author)
  • Feltoft, Claus LarsenCopenhagen University Hospital—Herlev and Gentofte, Kobenhavn, Denmark,Copenhagen Univ Hosp Herlev & Gentofte, Denmark (author)
  • Rasmussen, Åse KroghCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark (author)
  • Feldt-Rasmussen, UllaCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark (author)
  • Andreassen, MikkelCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark (author)
  • Klose, Marianne ChristinaCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark (author)
  • Nielsen, Torben LeoOdense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark (author)
  • Andersen, Marianne SkovsagerOdense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark (author)
  • Christensen, Louise LehmannOdense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark (author)
  • Krogh, JesperCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark (author)
  • Jarlov, AnneCopenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark (author)
  • Bollerslev, JensOslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway (author)
  • Nermoen, IngridAkershus University Hospital, lørenskog, Norway,Akershus Univ Hosp, Norway (author)
  • Oksnes, MarianneHaukeland University Hospital, Bergen, Norway,Haukeland Hosp, Norway (author)
  • Dahlqvist, PerUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden,Umea Univ, Sweden; Norrlands Univ Hosp, Sweden(Swepub:umu)perdat96 (author)
  • Olsson, TommyUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden,Umea Univ, Sweden; Norrlands Univ Hosp, Sweden(Swepub:umu)tool0003 (author)
  • Berinder, KatarinaKarolinska University Hospital, Sweden,Karolinska Univ Hosp, Sweden (author)
  • Hoybye, CharlotteKarolinska University Hospital, Sweden,Karolinska Univ Hosp, Sweden (author)
  • Petersson, MariaKarolinska University Hospital, Sweden,Karolinska Univ Hosp, Sweden (author)
  • Akerman, Anna-karinSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, Sweden; Department of Medicine, Örebro University Hospital, Örebro, Sweden,Orebro Univ, Sweden (author)
  • Wahlberg, JeanetteDepartment of Medicine, Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Sweden (author)
  • Ekman, BertilLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN,Region Östergötland, Endokrinmedicinska kliniken,Department of Endocrinology and the Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden(Swepub:liu)berek83 (author)
  • Engstrom, Britt EdenUppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden (author)
  • Johannsson, GudmundurDepartment of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden (author)
  • Ragnarsson, OskarDepartment of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Sweden (author)
  • Olsson, DanielDepartment of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden; Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; AstraZeneca, Sweden (author)
  • Sigurjónsdóttir, Helga ÁgústaThe National University Hospital of Iceland, Gothenburg, Iceland; School of Medicine, University of Iceland, Reykjavik, Iceland,Natl Univ Hosp Iceland, Iceland; Univ Iceland, Iceland (author)
  • Fougner, Stine LyngviDepartment of Endocrinology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway,Trondheim Reg & Univ Hosp, Norway; Norwegian Univ Sci & Technol NTNU, Norway (author)
  • Matikainen, NiinaHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland (author)
  • Vehkavaara, SatuHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland (author)
  • Metso, SaaraTampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland (author)
  • Jaatinen, PiaTampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland (author)
  • Hämäläinen, PäiviTampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland (author)
  • Rintamäki, ReetaKuopio University Hospital, Kuopio, Finland,Kuopio Univ Hosp, Finland (author)
  • Yliaska, IinaOulu University Hospital, Oulu, Finland,Oulu Univ Hosp, Finland (author)
  • Immonen, HeidiTurku University Hospital, Turku, Finland,Turku Univ Hosp, Finland (author)
  • Mäkimattila, SariHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland (author)
  • Cederberg-Tamminen, HennaHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland (author)
  • Viukari, MariannaHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland (author)
  • Nevalainen, PasiTampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland (author)
  • Nuutila, PirjoTurku University Hospital, Turku, Finland,Turku Univ Hosp, Finland (author)
  • Schalin-Jäntti, CamillaHelsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland (author)
  • Burman, PiaSkåne University Hospital, Lund University, Malmö, Sweden,Lund Univ, Sweden (author)
  • Jørgensen, Jens Otto LundeDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark (author)
  • Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, DenmarkAarhus Univ Hosp, Denmark (creator_code:org_t)

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  • In:Clinical Endocrinology: John Wiley & Sons0300-06641365-2265

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