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Acromegaly management in the nordic countries : a Delphi consensus survey

Arlien-Søborg, Mai C. (författare)
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
Dal, Jakob (författare)
Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark; Steno Diabetes Center North Jutland, Aalborg, Denmark,Aalborg Univ Hosp, Denmark; Steno Diabet Ctr North Jutland, Denmark
Heck, Ansgar (författare)
Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway
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Stochholm, Kirstine (författare)
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
Husted, Eigil (författare)
Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark,Aalborg Univ Hosp, Denmark
Feltoft, Claus Larsen (författare)
Copenhagen University Hospital—Herlev and Gentofte, Kobenhavn, Denmark,Copenhagen Univ Hosp Herlev & Gentofte, Denmark
Rasmussen, Åse Krogh (författare)
Copenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
Feldt-Rasmussen, Ulla (författare)
Copenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
Andreassen, Mikkel (författare)
Copenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
Klose, Marianne Christina (författare)
Copenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
Nielsen, Torben Leo (författare)
Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
Andersen, Marianne Skovsager (författare)
Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
Christensen, Louise Lehmann (författare)
Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
Krogh, Jesper (författare)
Copenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
Jarlov, Anne (författare)
Copenhagen University Hospital, Kobenhavn, Denmark,Copenhagen Univ Hosp, Denmark
Bollerslev, Jens (författare)
Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway
Nermoen, Ingrid (författare)
Akershus University Hospital, lørenskog, Norway,Akershus Univ Hosp, Norway
Oksnes, Marianne (författare)
Haukeland University Hospital, Bergen, Norway,Haukeland Hosp, Norway
Dahlqvist, Per (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden,Umea Univ, Sweden; Norrlands Univ Hosp, Sweden
Olsson, Tommy (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden,Umea Univ, Sweden; Norrlands Univ Hosp, Sweden
Berinder, Katarina (författare)
Karolinska University Hospital, Sweden,Karolinska Univ Hosp, Sweden
Hoybye, Charlotte (författare)
Karolinska University Hospital, Sweden,Karolinska Univ Hosp, Sweden
Petersson, Maria (författare)
Karolinska University Hospital, Sweden,Karolinska Univ Hosp, Sweden
Akerman, Anna-karin (författare)
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Sweden; Department of Medicine, Örebro University Hospital, Örebro, Sweden,Orebro Univ, Sweden
Wahlberg, Jeanette (författare)
Department of Medicine, Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Sweden
Ekman, Bertil (författare)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN,Region Östergötland, Endokrinmedicinska kliniken,Department of Endocrinology and the Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
Engstrom, Britt Eden (författare)
Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden
Johannsson, Gudmundur (författare)
Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
Ragnarsson, Oskar (författare)
Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Sweden
Olsson, Daniel (författare)
Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden; Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; AstraZeneca, Sweden
Sigurjónsdóttir, Helga Ágústa (författare)
The National University Hospital of Iceland, Gothenburg, Iceland; School of Medicine, University of Iceland, Reykjavik, Iceland,Natl Univ Hosp Iceland, Iceland; Univ Iceland, Iceland
Fougner, Stine Lyngvi (författare)
Department of Endocrinology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway,Trondheim Reg & Univ Hosp, Norway; Norwegian Univ Sci & Technol NTNU, Norway
Matikainen, Niina (författare)
Helsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
Vehkavaara, Satu (författare)
Helsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
Metso, Saara (författare)
Tampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland
Jaatinen, Pia (författare)
Tampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland
Hämäläinen, Päivi (författare)
Tampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland
Rintamäki, Reeta (författare)
Kuopio University Hospital, Kuopio, Finland,Kuopio Univ Hosp, Finland
Yliaska, Iina (författare)
Oulu University Hospital, Oulu, Finland,Oulu Univ Hosp, Finland
Immonen, Heidi (författare)
Turku University Hospital, Turku, Finland,Turku Univ Hosp, Finland
Mäkimattila, Sari (författare)
Helsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
Cederberg-Tamminen, Henna (författare)
Helsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
Viukari, Marianna (författare)
Helsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
Nevalainen, Pasi (författare)
Tampere University Hospital, Tampere, Finland,Tampere Univ Hosp, Finland
Nuutila, Pirjo (författare)
Turku University Hospital, Turku, Finland,Turku Univ Hosp, Finland
Schalin-Jäntti, Camilla (författare)
Helsinki University Hospital, Helsinki, Finland,Helsinki Univ Hosp, Finland
Burman, Pia (författare)
Skåne University Hospital, Lund University, Malmö, Sweden,Lund Univ, Sweden
Jørgensen, Jens Otto Lunde (författare)
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
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 (creator_code:org_t)
2024
2024
Engelska.
Ingår i: Clinical Endocrinology. - : John Wiley & Sons. - 0300-0664 .- 1365-2265.
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.Methods: A Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1−7). Consensus was defined as ≥80% of panelists rating their agreement as ≥5 or ≤3 on the Likert-type scale.Results: Consensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.Conclusion: This consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

acromegaly
Delphi
dopamine agonist
growth hormone
growth hormone receptor antagonist
insulin-like growth factor i
somatostatin

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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