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Availability, usage...
Availability, usage, and preferences of estradiol and progestogen preparations for puberty induction from a multicentral perspective
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- Gawlik-Starzyk, Aneta M. (författare)
- Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
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- Wiȩcek, Małgorzata (författare)
- Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
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- Matthews, Debbie (författare)
- Newcastle Upon Tyne Nhs Foundation Trust, Newcastle Upon Tyne, United Kingdom
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- Öhman Kriström, Berit (författare)
- Umeå universitet,Pediatrik
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- Van Der Velden, Janielle A.E.M. (författare)
- Department of Pediatrics, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands
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- Sas, Theo C.J. (författare)
- Department of Pediatric Endocrinology, Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, Netherlands; Diabeter, National Diabetes Care and Research Center, Rotterdam, Netherlands
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- Wasniewska, Malgorzata (författare)
- Department of Human Pathology of Adulthood and Childhood, Unit of Pediatrics, University of Messina, Messina, Italy
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- Verlinde, Siska (författare)
- Belgian Study Group of Paediatric Endocrinology and Diabetes, Brussels, Belgium
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- Brain, Caroline (författare)
- Department of Endocrinology, Great Ormond Street Hospital Nhs Foundation Trust, London, United Kingdom
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- Smyth, Arlene (författare)
- Executive Officer Turner Syndrome Support Society, Clydebank Business Park, Glasgow, United Kingdom
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- Donaldson, Malcolm David Cairns (författare)
- Glasgow University School of Medicine, Glasgow, United Kingdom
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Hormone Research in Paediatrics. - : S. Karger. - 1663-2818 .- 1663-2826.
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Natural oestrogen administration as oral or transdermal 17β-estradiol is recommended for pubertal induction in girls with hypogonadism. However, suitable low-dose formulations are not consistently available globally. This questionnaire study aimed to identify the current availability of oestrogen and progesterone preparations worldwide.Methods: Endorsed by the ESPE Turner Syndrome Working Group, the questionnaire targeted paediatric endocrinologists. Questions focused on accessibility of oral/transdermal 17β-estradiol and progestogen preparations. Responses were collected through a SurveyMonkey survey disseminated via ESPE channels, direct outreach, and conferences from June 2020 to December 2022.Results: Participation included 229 healthcare professionals from 45 countries. Oral and transdermal 17β-estradiol in adult dosage was highly accessible (86.5% and 84.3%), with transdermal administration the preferred form (62.8%). Most commonly available estradiol preparations included 50 μg patches (32 countries) and 1 or 2 mg tablets (65.8% and 71.1% countries). However, 0.5 mg 17β-estradiol tablets were available in only 20% of respondents from 8 countries. Patches delivering 14 or 25 μg/day of 17β-estradiol were available in 3 and 20 countries, respectively. Oral progestogen had widespread availability (96.0%) and preference (87.0%), while transdermal usage was limited to 15.2% of respondents.Conclusion: This study highlights global challenges in accessing suitable hormone preparations for female pubertal induction. In most countries, the lowest dose of the estradiol is 50 μg for patches and 2 mg for tablets. Appropriate low-dose 17β-estradiol tablets are much less available than low-dose patches. Our survey underscores the importance of adapting guidelines to local availability, and the need for improved accessibility to address these global disparities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Availability
- Hormone replacement therapy
- Hypogonadism
- Oestrogens
- Progesterone
- Puberty induction
- Turner syndrome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gawlik-Starzyk, ...
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Wiȩcek, Małgorza ...
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Matthews, Debbie
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Öhman Kriström, ...
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Van Der Velden, ...
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Sas, Theo C.J.
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visa fler...
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Wasniewska, Malg ...
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Verlinde, Siska
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Brain, Caroline
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Smyth, Arlene
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Donaldson, Malco ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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Hormone Research ...
- Av lärosätet
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Umeå universitet