WFRF:(Bryan J)
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Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
- van Es, Michael A (author)
- van Vught, Paul W J (author)
- Blauw, Hylke M (author)
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- Franke, Lude (author)
- Saris, Christiaan G J (author)
- Van den Bosch, Ludo (author)
- de Jong, Sonja W (author)
- de Jong, Vianney (author)
- Baas, Frank (author)
- van't Slot, Ruben (author)
- Lemmens, Robin (author)
- Schelhaas, Helenius J (author)
- Sleegers, Kristel (author)
- Van Broeckhoven, Christine (author)
- Schymick, Jennifer C (author)
- Traynor, Bryan J (author)
- Wokke, John H J (author)
- Wijmenga, Cisca (author)
- Robberecht, Wim (author)
- Veldink, Jan H (author)
- Ophoff, Roel A (author)
- van den Berg, Leonard H (author)
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- (creator_code:org_t)
- 2007-12-16
- 2008
- English.
- In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:1, s. 29-31
- Journal article (peer-reviewed)
Abstract
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- We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
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- de Jong, Sonja W
- de Jong, Vianney
- Baas, Frank
- van't Slot, Rube ...
- Lemmens, Robin
- Schelhaas, Helen ...
- Birve, Anna
- Sleegers, Kriste ...
- Van Broeckhoven, ...
- Schymick, Jennif ...
- Traynor, Bryan J
- Wokke, John H J
- Wijmenga, Cisca
- Robberecht, Wim
- Andersen, Peter ...
- Veldink, Jan H
- Ophoff, Roel A
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