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Celiac disease reve...
Celiac disease revealed in 3% of Swedish 12-year-olds born during an epidemic
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- Myléus, Anna, 1978- (author)
- Umeå universitet,Epidemiologi och folkhälsovetenskap,Umeå University
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- Ivarsson, Anneli (author)
- Lund University,Lunds universitet,Umeå universitet,Epidemiologi och folkhälsovetenskap,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Umeå University
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- Webb, Charlotta (author)
- Lund University Hospital
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- Danielsson, Lars (author)
- Norrtälje Hospital
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- Hernell, Olle (author)
- Umeå universitet,Pediatrik,Umeå University
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- Högberg, Lotta (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Norrköping
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- Karlsson, Eva (author)
- Växjö Hospital
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- Lagerqvist, Carina (author)
- Umeå universitet,Pediatrik,Umeå University
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- Norström, Fredrik (author)
- Umeå universitet,Epidemiologi och folkhälsovetenskap,Umeå University
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- Rosén, Anna (author)
- Umeå universitet,Epidemiologi och folkhälsovetenskap,Umeå University
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- Sandström, Olof (author)
- Umeå universitet,Pediatrik,Umeå University
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- Stenhammar, Lars (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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- Stenlund, Hans (author)
- Umeå universitet,Epidemiologi och folkhälsovetenskap,Umeå University
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- Wall, Stig (author)
- Umeå universitet,Epidemiologi och folkhälsovetenskap,Umeå University
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Carlsson, Annelie (author)
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(creator_code:org_t)
- New York : Raven P, 2009
- 2009
- English.
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In: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - New York : Raven P. - 0277-2116 .- 1536-4801. ; 49:2, s. 170-176
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Objetive: Sweden experienced a marked epidemic of celiac disease between 1984 and 1996 in children younger than 2 years of age, partly explained by changes in infant feeding. The objective of this study was to determine the prevalence of celiac disease in 12-year-olds born during the epidemic (1993), including both symptomatic and screening detected cases.Patients and methods: All sixth-grade children in participating schools were invited (n = 10,041). Symptomatic and, therefore, previously diagnosed celiac disease cases were ascertained through the National Swedish Childhood Celiac Disease Register and/or medical records. All serum samples were analyzed for antihuman tissue transglutaminase (tTG)-IgA (Celikey), and serum-IgA, and some for tTG-IgG and endomysial antibodies. A small intestinal biopsy was recommended for all children with suspected undiagnosed celiac disease.Results: Participation was accepted by 7567 families (75%). Previously diagnosed celiac disease was found in 67 children; 8.9/1000 (95% confidence interval [CI] 6.7-11). In another 192 children, a small intestinal biopsy was recommended and was performed in 180. Celiac disease was verified in 145 children, 20/1000 (95% CI 17-23). The total prevalence was 29/1000 (95% CI 25-33).Conclusions: The celiac disease prevalence of 29/1000 (3%)-with two thirds of cases undiagnosed before screening-is 3-fold higher than the usually suggested prevalence of 1%. When these 12-year-olds were infants, the prevailing feeding practice was to introduce gluten abruptly, often without ongoing breast-feeding, which might have contributed to this unexpectedly high prevalence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Celiac disease
- Children
- Infant nutrition
- Prevalence
- Screening
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Myléus, Anna, 19 ...
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Ivarsson, Anneli
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Webb, Charlotta
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Danielsson, Lars
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Hernell, Olle
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Högberg, Lotta
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show more...
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Karlsson, Eva
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Lagerqvist, Cari ...
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Norström, Fredri ...
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Rosén, Anna
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Sandström, Olof
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Stenhammar, Lars
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Stenlund, Hans
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Wall, Stig
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Carlsson, Anneli ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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MEDICAL AND HEAL ...
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and Pediatrics
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Umeå University
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Lund University
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Linköping University