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Effects of contact ...
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Tripoliti, Elina
(author)
Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation.
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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2008-09-11
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Wiley,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-25345
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25345URI
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https://doi.org/10.1002/mds.22296DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.
Added entries (persons, corporate bodies, meetings, titles ...)
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Zrinzo, Ludvic
(author)
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Martinez-Torres, Irene
(author)
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Tisch, Stephen
(author)
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Frost, Eleanor
(author)
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Borrell, Ellie
(author)
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Hariz, Marwan IUmeå universitet,Neurokirurgi
(author)
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Limousin, Patricia
(author)
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Umeå universitetNeurokirurgi
(creator_code:org_t)
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