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  • Cegelski, LynetteDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA. (author)

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-10-25
  • Nature Publishing Group,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-26861
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26861URI
  • https://doi.org/10.1038/nchembio.242DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Published online 25 October 2009
  • Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli (UPEC) and other Enterobacteriaceae. Ring-fused 2-pyridones, such as FN075 and BibC6, inhibited curli biogenesis in UPEC and prevented the in vitro polymerization of the major curli subunit protein CsgA. The curlicides FN075 and BibC6 share a common chemical lineage with other ring-fused 2-pyridones termed pilicides. Pilicides inhibit the assembly of type1pili, which are required for pathogenesis during urinary tract infection. Notably, the curlicides retained pilicide activities and inhibited both curli-dependent and type 1–dependent biofilms. Furthermore, pretreatment of UPEC with FN075 significantly attenuated virulence in a mouse model of urinary tract infection. Curli and type 1pili exhibited exclusive and independent roles in promoting UPEC biofilms, and curli provided a fitness advantage in vivo. Thus, the ability of FN075 to block the biogenesis of both curli and type 1pili endows unique anti-biofilm and anti-virulence activities on these compounds.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Pinkner, Jerome SDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA (author)
  • Hammer, Neal DDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA (author)
  • Cusumano, Corinne KDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA (author)
  • Hung, Chia SDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA (author)
  • Chorell, Erik,1980-Umeå universitet,Kemiska institutionen(Swepub:umu)erkchl00 (author)
  • Åberg, Veronica,1976-Umeå universitet,Kemiska institutionen(Swepub:umu)veaabg97 (author)
  • Walker, Jennifer NDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA (author)
  • Seed, Patrick CDepartments of Pediatrics and Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA (author)
  • Almqvist, FredrikUmeå universitet,Kemiska institutionen(Swepub:umu)fral0001 (author)
  • Chapman, Matthew RDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA (author)
  • Hultgren, Scott JDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA (author)
  • Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA (creator_code:org_t)

Related titles

  • In:Nature Chemical Biology: Nature Publishing Group5:12, s. 913-9191552-44501552-4469

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