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Small-molecule inhi...
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Cegelski, LynetteDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
(author)
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-10-25
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Nature Publishing Group,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-26861
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26861URI
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https://doi.org/10.1038/nchembio.242DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Published online 25 October 2009
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Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli (UPEC) and other Enterobacteriaceae. Ring-fused 2-pyridones, such as FN075 and BibC6, inhibited curli biogenesis in UPEC and prevented the in vitro polymerization of the major curli subunit protein CsgA. The curlicides FN075 and BibC6 share a common chemical lineage with other ring-fused 2-pyridones termed pilicides. Pilicides inhibit the assembly of type1pili, which are required for pathogenesis during urinary tract infection. Notably, the curlicides retained pilicide activities and inhibited both curli-dependent and type 1–dependent biofilms. Furthermore, pretreatment of UPEC with FN075 significantly attenuated virulence in a mouse model of urinary tract infection. Curli and type 1pili exhibited exclusive and independent roles in promoting UPEC biofilms, and curli provided a fitness advantage in vivo. Thus, the ability of FN075 to block the biogenesis of both curli and type 1pili endows unique anti-biofilm and anti-virulence activities on these compounds.
Added entries (persons, corporate bodies, meetings, titles ...)
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Pinkner, Jerome SDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
(author)
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Hammer, Neal DDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
(author)
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Cusumano, Corinne KDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
(author)
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Hung, Chia SDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
(author)
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Chorell, Erik,1980-Umeå universitet,Kemiska institutionen(Swepub:umu)erkchl00
(author)
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Åberg, Veronica,1976-Umeå universitet,Kemiska institutionen(Swepub:umu)veaabg97
(author)
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Walker, Jennifer NDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
(author)
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Seed, Patrick CDepartments of Pediatrics and Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA
(author)
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Almqvist, FredrikUmeå universitet,Kemiska institutionen(Swepub:umu)fral0001
(author)
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Chapman, Matthew RDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
(author)
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Hultgren, Scott JDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
(author)
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Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
(creator_code:org_t)
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In:Nature Chemical Biology: Nature Publishing Group5:12, s. 913-9191552-44501552-4469
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