Sökning: WFRF:(Cegelski Lynette)
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Small-molecule inhi...
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation
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- Cegelski, Lynette (författare)
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
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- Pinkner, Jerome S (författare)
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
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- Hammer, Neal D (författare)
- Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
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- Cusumano, Corinne K (författare)
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
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- Hung, Chia S (författare)
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
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- Chorell, Erik, 1980- (författare)
- Umeå universitet,Kemiska institutionen
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- Åberg, Veronica, 1976- (författare)
- Umeå universitet,Kemiska institutionen
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- Walker, Jennifer N (författare)
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
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- Seed, Patrick C (författare)
- Departments of Pediatrics and Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA
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- Almqvist, Fredrik (författare)
- Umeå universitet,Kemiska institutionen
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- Chapman, Matthew R (författare)
- Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
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- Hultgren, Scott J (författare)
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA
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Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA (creator_code:org_t)
- 2009-10-25
- 2009
- Engelska.
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Ingår i: Nature Chemical Biology. - : Nature Publishing Group. - 1552-4450 .- 1552-4469. ; 5:12, s. 913-919
- Relaterad länk:
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http://www.nature.co...
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli (UPEC) and other Enterobacteriaceae. Ring-fused 2-pyridones, such as FN075 and BibC6, inhibited curli biogenesis in UPEC and prevented the in vitro polymerization of the major curli subunit protein CsgA. The curlicides FN075 and BibC6 share a common chemical lineage with other ring-fused 2-pyridones termed pilicides. Pilicides inhibit the assembly of type1pili, which are required for pathogenesis during urinary tract infection. Notably, the curlicides retained pilicide activities and inhibited both curli-dependent and type 1–dependent biofilms. Furthermore, pretreatment of UPEC with FN075 significantly attenuated virulence in a mouse model of urinary tract infection. Curli and type 1pili exhibited exclusive and independent roles in promoting UPEC biofilms, and curli provided a fitness advantage in vivo. Thus, the ability of FN075 to block the biogenesis of both curli and type 1pili endows unique anti-biofilm and anti-virulence activities on these compounds.
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Cegelski, Lynett ...
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Pinkner, Jerome ...
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Hammer, Neal D
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Cusumano, Corinn ...
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Hung, Chia S
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Chorell, Erik, 1 ...
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Åberg, Veronica, ...
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Walker, Jennifer ...
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Seed, Patrick C
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Almqvist, Fredri ...
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Chapman, Matthew ...
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Hultgren, Scott ...
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Umeå universitet