id:"swepub:oai:DiVA.org:umu-3086"
Search: id:"swepub:oai:DiVA.org:umu-3086" > Beneficial and detr...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Guo, YongzhiUmeå universitet,Institutionen för medicinsk kemi och biofysik (author)
Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- 2011-09-12
- Public Library of Science,2011
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-3086
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3086URI
- https://doi.org/10.1371/journal.pone.0024774DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Previously included in thesis in manuscript form, with title "Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis".
- Plasmin has been proposed to be an important mediator during inflammation/infection. In this study, by using mice lacking genes for plasminogen, tissue-type plasminogen activator (tPA), and urokinase-type PA (uPA), we have investigated the functional roles of active plasmin in infection and sepsis. Two models were used: an infection model by intravenous injection of 1x10(7) CFU of S. aureus, and a sepsis model by intravenous injection of 1.6x10(8) CFU of S. aureus. We found that in the infection model, wild-type (WT) mice showed significantly higher survival rates than plasminogen-deficient (plg(-/-)) mice. However, in the sepsis model, plg(-/-) or tPA(-/-)/uPA(-/-) mice showed the highest survival rate whereas WT and tPA(+/-)/uPA(+/-) mice showed the lowest survival rate, and plg(+/-), tPA(-/-), and uPA(-/-) mice had an intermediate survival rate. These results indicate that the levels of active plasmin are critical in determining the survival rate in the sepsis, partly through high levels of inflammatory cytokines and enhanced STAT3 activation. We conclude that plasmin is beneficial in infection but promotes the production of inflammatory cytokines in sepsis that may cause tissue destruction, diminished neutrophil function, and an impaired capacity to kill bacteria which eventually causes death of these mice.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Li, JinanUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)jili0010 (author)
- Hagström, ElinUmeå universitet,Institutionen för medicinsk kemi och biofysik (author)
- Ny, TorUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)tony0001 (author)
- Umeå universitetInstitutionen för medicinsk kemi och biofysik (creator_code:org_t)
Related titles
- In:PLOS ONE: Public Library of Science6:91932-6203
Internet link
- https://doi.org/10.1371/journal.pone.0024774Fulltext
- https://umu.diva-portal.org/smash/get/diva2:141540/FULLTEXT01.pdffulltext:print
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024774&type=printable
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3086
- https://doi.org/10.1371/journal.pone.0024774
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Guo, Yongzhi
- Li, Jinan
- Hagström, Elin
- Ny, Tor
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- Articles in the publication
- PLOS ONE
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
