Predictors of survival after aortic valve replacement in patients with low-flow and high-gradient aortic stenosis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Wen Wei) > (2005-2009) > Predictors of survi...

Ding, Wen-HongDepartment of Paediatric Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing, China (författare)

Predictors of survival after aortic valve replacement in patients with low-flow and high-gradient aortic stenosis

Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

2009-08-20
Oxford University Press,2009
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:umu-30998
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30998URI
https://doi.org/10.1093/eurjhf/hfp096DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

AIMS: To identify predictors of survival following aortic valve replacement (AVR) in patients with low-flow and high-gradient aortic stenosis (AS).METHODS AND RESULTS: Eighty-six patients (aged 71 +/- 10 years) with severe AS [aortic valve mean pressure gradient >40 mmHg or valve area <1.0 cm(2)] and left ventricular (LV) dysfunction [ejection fraction (EF) <50%] underwent AVR. Cox proportional hazards were used to identify independent clinical and echocardiographic predictors of mortality. Operative (30-day) mortality was 10%. Peri-operative mortality was associated with lower mean LVEF, higher mitral E:A ratio, peak systolic pulmonary artery pressure (PSPAP), and serum creatinine (by 12%, 2.3, 28 mmHg, and 74 mmol/L, respectively, all P < 0.001), NYHA class III-IV (100 vs. 65%), concomitant CABG (89 vs. 55%), urgent surgery (78 vs. 35%), and longer bypass-time (by 28 min, all P < 0.05). Mortality at 4 years was 17%. Univariate predictors [hazard ratio (HR)] of 4-year mortality were: lower EF (HR 0.68 per % increase, P < 0.001), presence of restrictive LV filling (HR: 3.52, P < 0.001), raised PSPAP (HR: 1.07, P < 0.001), and CABG (HR: 4.93, P = 0.037). However, only low EF (<40%, HR 0.74, P = 0.030), the presence of restrictive filling (HR 1.77, P = 0.033), and raised PSPAP (>45 mmHg, HR 2.71, P = 0.010) remained as independent predictors after multivariate analysis. CONCLUSION: The severity of pre-operative systolic and diastolic LV dysfunction is the major predictor of mortality following AVR for low-flow and high-gradient AS.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Aortic stenosis
Aortic valve replacement
Low-flow
High-gradient
Survival

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lam, Yat-YinDivision of Cardiology, Department of Medicine and Therapeutics Prince of Wales Hospital, Li Ka Shing Institute of Health and Sciences, Institute of Vascular Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China (författare)
Duncan, AlisonRoyal Brompton Hospital, London, UK (författare)
Li, WeiRoyal Brompton Hospital, London, UK (författare)
Lim, EricRoyal Brompton Hospital, London, UK (författare)
Kaya, Mehmet GDepartment of Cardiology, Erciyes University, Erciyes, Turkey (författare)
Chung, RobinRoyal Brompton Hospital, London, UK (författare)
Pepper, John RRoyal Brompton Hospital, London, UK (författare)
Henein, Michael YUmeå universitet,Medicin,Heart Centre, Norrlands University Hospital, Umeå, Sweden(Swepub:umu)mihe0015 (författare)
Department of Paediatric Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing, ChinaDivision of Cardiology, Department of Medicine and Therapeutics Prince of Wales Hospital, Li Ka Shing Institute of Health and Sciences, Institute of Vascular Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China (creator_code:org_t)

Sammanhörande titlar

Ingår i:European Journal of Heart Failure: Oxford University Press11:9, s. 897-9021388-98421879-0844

Internetlänk

Hitta via bibliotek

European Journal of Heart Failure (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Ding, Wen-Hong; Lam, Yat-Yin; Duncan, Alison; Li, Wei; Lim, Eric; Kaya, Mehmet G; visa fler...; Chung, Robin; Pepper, John R; Henein, Michael ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: European Journal ...

Av lärosätet: Umeå universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se