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Chronic intermitten...
Chronic intermittent L-DOPA treatment induces changes in dopamine release
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- Lundblad, Martin (author)
- Lund University,Lunds universitet,Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups
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- af Bjerkén, Sara (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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Cenci, Angela M. (author)
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Pomerleau, Francois (author)
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Gerhardt, Greg A. (author)
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- Strömberg, Ingrid (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Cenci Nilsson, Angela (author)
- Lund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups
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(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
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In: Journal of Neurochemistry. - : Wiley. - 0022-3042 .- 1471-4159. ; 108:4, s. 998-1008
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http://dx.doi.org/10...
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Abstract
Subject headings
Close
- 3,4-Dihydroxyphenyl-l-alanine (l-DOPA)-induced dyskinesia often develops as a side effect of chronic l-DOPA therapy. This study was undertaken to investigate dopamine (DA) release upon l-DOPA treatment. Chronoamperometric measurements were performed in unilaterally DA-depleted rats, chronically treated with l-DOPA, resulting in dyskinetic and non-dyskinetic animals. Normal and lesioned l-DOPA naïve animals were used as controls. Potassium-evoked DA releases were significantly reduced in intact sides of animals undertaken chronic l-DOPA treatment, independent on dyskinetic behavior. Acute l-DOPA further attenuated the amplitude of the DA release in the control sides. In DA-depleted striata, no difference was found in potassium-evoked DA releases, and acute l-DOPA did not affect the amplitude. While immunoreactivity to serotonin uptake transporter was higher in lesioned striata of animals displaying dyskinetic behavior, no correlation could be documented between serotonin transporter-positive nerve fiber density and the amplitude of released DA. In conclusions, the amplitude of potassium-evoked DA release is attenuated in intact striatum after chronic intermittent l-DOPA treatment. No change in amplitude was found in DA-denervated sides of either dyskinetic or non-dyskinetic animals, while release kinetics were changed. This indicates the importance of studying DA release dynamics for the understanding of both beneficial and adverse effects of l-DOPA replacement therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- 3
- 4-dihydroxyphenyl-l-alanine
- 3
- 4-dihydroxyphenyl-l-alanine induced dyskinesia
- 5-hydroxytryptamine or serotonin
- chronoamperometry
- dopamine
- serotonin transporter
- MEDICINE
- MEDICIN
- chronoamperometry
- dopamine
- serotonin transporter
- 5-hydroxytryptamine or serotonin
- dyskinesia
- 4-dihydroxyphenyl-l-alanine induced
- 3
- 4-dihydroxyphenyl-l-alanine
Publication and Content Type
- ref (subject category)
- art (subject category)
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