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Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations : a nested case-control study
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Jenab, Mazda (author)
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Bueno-de-Mesquita, H Bas (author)
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Ferrari, Pietro (author)
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van Duijnhoven, Franzel J B (author)
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Norat, Teresa (author)
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Pischon, Tobias (author)
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Jansen, Eugène H J M (author)
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Slimani, Nadia (author)
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Byrnes, Graham (author)
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Rinaldi, Sabina (author)
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Tjønneland, Anne (author)
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Olsen, Anja (author)
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Overvad, Kim (author)
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Boutron-Ruault, Marie-Christine (author)
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Clavel-Chapelon, Françoise (author)
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Morois, Sophie (author)
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Kaaks, Rudolf (author)
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Linseisen, Jakob (author)
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Boeing, Heiner (author)
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Bergmann, Manuela M (author)
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Trichopoulou, Antonia (author)
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Misirli, Gesthimani (author)
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Trichopoulos, Dimitrios (author)
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Berrino, Franco (author)
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Vineis, Paolo (author)
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Panico, Salvatore (author)
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Palli, Domenico (author)
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Tumino, Rosario (author)
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Ros, Martine M (author)
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van Gils, Carla H (author)
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Peeters, Petra H (author)
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Brustad, Magritt (author)
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Lund, Eiliv (author)
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Tormo, María-José (author)
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Ardanaz, Eva (author)
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Rodríguez, Laudina (author)
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Sánchez, Maria-José (author)
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Dorronsoro, Miren (author)
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Gonzalez, Carlos A (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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Roddam, Andrew (author)
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Key, Timothy J (author)
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Khaw, Kay-Tee (author)
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Autier, Philippe (author)
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Hainaut, Pierre (author)
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Riboli, Elio (author)
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(creator_code:org_t)
- 2010-01-21
- 2010
- English.
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In: BMJ. British Medical Journal. - : BMJ Publishing Group. - 0959-8146 .- 0959-535X. ; 340, s. b5500-
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https://www.bmj.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVE: To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations. DESIGN: Nested case-control study. Setting The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries. PARTICIPANTS: 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controls MAIN OUTCOME MEASURES: Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders. RESULTS: 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend <0.001). Compared with a pre-defined mid-level concentration of 25-(OH)D (50.0-75.0 nmol/l), lower levels were associated with higher colorectal cancer risk (<25.0 nmol/l: incidence rate ratio 1.32 (95% confidence interval 0.87 to 2.01); 25.0-49.9 nmol/l: 1.28 (1.05 to 1.56), and higher concentrations associated with lower risk (75.0-99.9 nmol/l: 0.88 (0.68 to 1.13); >or=100.0 nmol/l: 0.77 (0.56 to 1.06)). In analyses by quintile of 25-(OH)D concentration, patients in the highest quintile had a 40% lower risk of colorectal cancer than did those in the lowest quintile (P<0.001). Subgroup analyses showed a strong association for colon but not rectal cancer (P for heterogeneity=0.048). Greater dietary intake of calcium was associated with a lower colorectal cancer risk. Dietary vitamin D was not associated with disease risk. Findings did not vary by sex and were not altered by corrections for season or month of blood donation. CONCLUSIONS: The results of this large observational study indicate a strong inverse association between levels of pre-diagnostic 25-(OH)D concentration and risk of colorectal cancer in western European populations. Further randomised trials are needed to assess whether increases in circulating 25-(OH)D concentration can effectively decrease the risk of colorectal cancer.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Patobiologi (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Pathobiology (hsv//eng)
Keyword
- Pathology
- Patologi
- patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jenab, Mazda
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Bueno-de-Mesquit ...
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Ferrari, Pietro
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van Duijnhoven, ...
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Norat, Teresa
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Pischon, Tobias
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show more...
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Jansen, Eugène H ...
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Slimani, Nadia
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Byrnes, Graham
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Rinaldi, Sabina
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Tjønneland, Anne
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Olsen, Anja
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Overvad, Kim
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Morois, Sophie
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Kaaks, Rudolf
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Linseisen, Jakob
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Boeing, Heiner
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Bergmann, Manuel ...
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Trichopoulou, An ...
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Misirli, Gesthim ...
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Trichopoulos, Di ...
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Berrino, Franco
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Vineis, Paolo
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Panico, Salvator ...
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Palli, Domenico
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Tumino, Rosario
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Ros, Martine M
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van Gils, Carla ...
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Peeters, Petra H
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Brustad, Magritt
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Lund, Eiliv
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Tormo, María-Jos ...
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Ardanaz, Eva
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Rodríguez, Laudi ...
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Sánchez, Maria-J ...
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Dorronsoro, Mire ...
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Gonzalez, Carlos ...
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Hallmans, Göran
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Palmqvist, Richa ...
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Roddam, Andrew
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Key, Timothy J
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Khaw, Kay-Tee
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Autier, Philippe
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Hainaut, Pierre
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Riboli, Elio
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- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
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and Pathobiology
- Articles in the publication
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BMJ. British Med ...
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BMJ
- By the university
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Umeå University