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  • Bäckman, LarsStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)

Dopamine D(1) receptors and age differences in brain activation during working memory

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Fayetteville, N.Y :Elsevier,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-31988
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31988URI
  • https://doi.org/10.1016/j.neurobiolaging.2009.10.018DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123212753URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-94949URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [(11)C] SCH23390 to determine dopamine D(1) receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load>lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D(1) BP in caudate and DLPFC. Statistical control of caudate and DLPFC D(1) binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.

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  • Karlsson, SariStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
  • Fischer, HåkanStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Psykologiska institutionen(Swepub:su)hkfi4392 (author)
  • Karlsson, PerKarolinska Institutet (author)
  • Brehmer, YvonneStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
  • Rieckmann, AnnaStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)(Swepub:umu)anri0051 (author)
  • Macdonald, Stuart WSAging Research Center, Karolinska Institutet, Gävlegatan 16, SE-113 30 Stockholm, Sweden; Department of Psychology, University of Victoria, Canada (author)
  • Farde, LarsKarolinska Institutet (author)
  • Nyberg, LarsUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)lany0001 (author)
  • Karolinska InstitutetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

Related titles

  • In:Neurobiology of AgingFayetteville, N.Y : Elsevier32:10, s. 1849-18560197-45801558-1497

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