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Differential effect...
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Goedecke, Julia H
(author)
Differential effects of abdominal adipose tissue distribution on insulin sensitivity in black and white South African women
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2012-09-06
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Wiley,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-32335
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32335URI
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https://doi.org/10.1038/oby.2009.73DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Black South African women are more insulin resistant than BMI-matched white women. The objective of the study was to characterize the determinants of insulin sensitivity in black and white South African women matched for BMI. A total of 57 normal-weight (BMI 18-25 kg/m(2)) and obese (BMI > 30 kg/m(2)) black and white premenopausal South African women underwent the following measurements: body composition (dual-energy X-ray absorptiometry), body fat distribution (computerized tomography (CT)), insulin sensitivity (S(I), frequently sampled intravenous glucose tolerance test), dietary intake (food frequency questionnaire), physical activity (Global Physical Activity Questionnaire), and socioeconomic status (SES, demographic questionnaire). Black women were less insulin sensitive (4.4 +/- 0.8 vs. 9.5 +/- 0.8 and 3.0 +/- 0.8 vs. 6.0 +/- 0.8 x 10(-5)/min/(pmol/l), for normal-weight and obese women, respectively, P < 0.001), but had less visceral adipose tissue (VAT) (P = 0.051), more abdominal superficial subcutaneous adipose tissue (SAT) (P = 0.003), lower SES (P < 0.001), and higher dietary fat intake (P = 0.001) than white women matched for BMI. S(I) correlated with deep and superficial SAT in both black (R = -0.594, P = 0.002 and R = 0.495, P = 0.012) and white women (R = -0.554, P = 0.005 and R = -0.546, P = 0.004), but with VAT in white women only (R = -0.534, P = 0.005). In conclusion, body fat distribution is differentially associated with insulin sensitivity in black and white women. Therefore, the different abdominal fat depots may have varying metabolic consequences in women of different ethnic origins.
Subject headings and genre
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apoptosis
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cisplatin
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malignant pleural mesothelioma (MPM)
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phase-contrast microscopy (PCM)
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scanning electron microscopy (SEM)
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Levitt, Naomi S
(author)
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Lambert, Estelle V
(author)
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Utzschneider, Kristina M
(author)
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Faulenbach, Mirjam V
(author)
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Dave, Joel A
(author)
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West, Sacha
(author)
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Victor, Hendriena
(author)
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Evans, JulietUmeå universitet,Medicin
(author)
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Olsson, TommyUmeå universitet,Medicin(Swepub:umu)tool0003
(author)
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Walker, Brian R
(author)
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Seckl, Jonathan R
(author)
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Kahn, Steven E
(author)
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Umeå universitetMedicin
(creator_code:org_t)
Related titles
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In:Obesity: Wiley17:8, s. 1506-15121930-73811930-739X
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West, Sacha
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Obesity
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