A novel stroke locus identified in a northern Sweden pedigree: linkage to chromosome 9q31-33.

A novel stroke locus identified in a northern Sweden pedigree : linkage to chromosome 9q31-33.

OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage.

Nilsson-Ardnor, SofieUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)soni0002 (author)
Wiklund, Per-GunnarUmeå universitet,Medicin (author)
Lindgren, P (author)
Escher, S A (author)
Lackovic, K (author)
Nilsson, A K (author)
Stegmayr, BirgittaUmeå universitet,Medicin(Swepub:umu)bist0001 (author)
Asplund, KjellUmeå universitet,Medicin(Swepub:umu)kjas0001 (author)
Holmberg, DanUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)daha0001 (author)
Umeå universitetMedicinsk och klinisk genetik (creator_code:org_t)

By the author/editor: Janunger, Tomas; Nilsson-Ardnor, ...; Wiklund, Per-Gun ...; Lindgren, P; Escher, S A; Lackovic, K; show more...; Nilsson, A K; Stegmayr, Birgit ...; Asplund, Kjell; Holmberg, Dan; show less...

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