Search: id:"swepub:oai:DiVA.org:umu-32341" >
A novel stroke locu...
-
Janunger, TomasUmeå universitet,Medicinsk och klinisk genetik
(author)
A novel stroke locus identified in a northern Sweden pedigree : linkage to chromosome 9q31-33.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-32341
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32341URI
-
https://doi.org/10.1212/WNL.0b013e3181c34b1dDOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Nilsson-Ardnor, SofieUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)soni0002
(author)
-
Wiklund, Per-GunnarUmeå universitet,Medicin
(author)
-
Lindgren, P
(author)
-
Escher, S A
(author)
-
Lackovic, K
(author)
-
Nilsson, A K
(author)
-
Stegmayr, BirgittaUmeå universitet,Medicin(Swepub:umu)bist0001
(author)
-
Asplund, KjellUmeå universitet,Medicin(Swepub:umu)kjas0001
(author)
-
Holmberg, DanUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)daha0001
(author)
-
Umeå universitetMedicinsk och klinisk genetik
(creator_code:org_t)
Related titles
-
In:Neurology73:21, s. 1767-17730028-38781526-632X
Internet link
Find in a library
-
Neurology
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Janunger, Tomas
-
Nilsson-Ardnor, ...
-
Wiklund, Per-Gun ...
-
Lindgren, P
-
Escher, S A
-
Lackovic, K
-
show more...
-
Nilsson, A K
-
Stegmayr, Birgit ...
-
Asplund, Kjell
-
Holmberg, Dan
-
show less...
- Articles in the publication
-
Neurology
- By the university
-
Umeå University