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Genome-wide associa...
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
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Lindgren, Cecilia M (author)
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Heid, Iris M (author)
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Randall, Joshua C (author)
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show more...
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Lamina, Claudia (author)
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Steinthorsdottir, Valgerdur (author)
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Qi, Lu (author)
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Speliotes, Elizabeth K (author)
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Thorleifsson, Gudmar (author)
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Willer, Cristen J (author)
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Herrera, Blanca M (author)
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Jackson, Anne U (author)
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Lim, Noha (author)
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Scheet, Paul (author)
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Soranzo, Nicole (author)
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Amin, Najaf (author)
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Aulchenko, Yurii S (author)
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Chambers, John C (author)
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Drong, Alexander (author)
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Luan, Jian'an (author)
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Lyon, Helen N (author)
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Rivadeneira, Fernando (author)
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Sanna, Serena (author)
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Timpson, Nicholas J (author)
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Zillikens, M Carola (author)
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Zhao, Jing Hua (author)
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Bandinelli, Stefania (author)
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Bennett, Amanda J (author)
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Bergman, Richard N (author)
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Bonnycastle, Lori L (author)
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Bumpstead, Suzannah J (author)
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Chanock, Stephen J (author)
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Cherkas, Lynn (author)
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Chines, Peter (author)
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Coin, Lachlan (author)
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Cooper, Cyrus (author)
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Crawford, Gabriel (author)
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Doering, Angela (author)
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Dominiczak, Anna (author)
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Doney, Alex S F (author)
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Ebrahim, Shah (author)
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Elliott, Paul (author)
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Erdos, Michael R (author)
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Estrada, Karol (author)
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Ferrucci, Luigi (author)
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Fischer, Guido (author)
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Forouhi, Nita G (author)
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Gieger, Christian (author)
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Grallert, Harald (author)
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Groves, Christopher J (author)
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Grundy, Scott (author)
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Guiducci, Candace (author)
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Hadley, David (author)
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- Hamsten, Anders (author)
- Karolinska Institutet
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Havulinna, Aki S (author)
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Hofman, Albert (author)
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Holle, Rolf (author)
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Holloway, John W (author)
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Illig, Thomas (author)
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Isomaa, Bo (author)
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Jacobs, Leonie C (author)
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Jameson, Karen (author)
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Jousilahti, Pekka (author)
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Karpe, Fredrik (author)
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Kuusisto, Johanna (author)
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Laitinen, Jaana (author)
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Lathrop, G Mark (author)
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Lawlor, Debbie A (author)
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Mangino, Massimo (author)
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McArdle, Wendy L (author)
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Meitinger, Thomas (author)
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Morken, Mario A (author)
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Morris, Andrew P (author)
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Munroe, Patricia (author)
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Narisu, Narisu (author)
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- Nordström, Anna (author)
- Umeå universitet,Idrottsmedicin,Geriatrik
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- Nordström, Peter (author)
- Umeå universitet,Idrottsmedicin,Geriatrik
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Oostra, Ben A (author)
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Palmer, Colin N A (author)
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Payne, Felicity (author)
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Peden, John F (author)
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Prokopenko, Inga (author)
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- Renström, Frida (author)
- Umeå universitet,Medicin
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Ruokonen, Aimo (author)
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Salomaa, Veikko (author)
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Sandhu, Manjinder S (author)
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Scott, Laura J (author)
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Scuteri, Angelo (author)
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Silander, Kaisa (author)
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Song, Kijoung (author)
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Yuan, Xin (author)
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Stringham, Heather M (author)
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Swift, Amy J (author)
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Tuomi, Tiinamaija (author)
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Uda, Manuela (author)
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Vollenweider, Peter (author)
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Waeber, Gerard (author)
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Wallace, Chris (author)
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Walters, G Bragi (author)
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Weedon, Michael N (author)
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Witteman, Jacqueline C M (author)
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Zhang, Cuilin (author)
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Zhang, Weihua (author)
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Caulfield, Mark J (author)
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Collins, Francis S (author)
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Davey Smith, George (author)
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Day, Ian N M (author)
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- Franks, Paul W (author)
- Lund University,Lunds universitet,Umeå universitet,Medicin,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Hattersley, Andrew T (author)
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Hu, Frank B (author)
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Jarvelin, Marjo-Riitta (author)
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Kong, Augustine (author)
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Kooner, Jaspal S (author)
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Laakso, Markku (author)
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Lakatta, Edward (author)
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Mooser, Vincent (author)
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Morris, Andrew D (author)
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Peltonen, Leena (author)
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Samani, Nilesh J (author)
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Spector, Timothy D (author)
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Strachan, David P (author)
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Tanaka, Toshiko (author)
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Tuomilehto, Jaakko (author)
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Uitterlinden, André G (author)
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van Duijn, Cornelia M (author)
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Wareham, Nicholas J (author)
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Waterworth, Dawn M (author)
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Boehnke, Michael (author)
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Deloukas, Panos (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Hunter, David J (author)
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Thorsteinsdottir, Unnur (author)
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Schlessinger, David (author)
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Wichmann, H-Erich (author)
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Frayling, Timothy M (author)
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Abecasis, Gonçalo R (author)
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Hirschhorn, Joel N (author)
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Loos, Ruth J F (author)
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Stefansson, Kari (author)
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Mohlke, Karen L (author)
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Barroso, Inês (author)
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McCarthy, Mark I (author)
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(creator_code:org_t)
- 2009-06-26
- 2009
- English.
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In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 5:6, s. e1000508-
- Related links:
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https://journals.plo...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lindgren, Cecili ...
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Heid, Iris M
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Randall, Joshua ...
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Lamina, Claudia
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Steinthorsdottir ...
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Qi, Lu
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show more...
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Speliotes, Eliza ...
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Thorleifsson, Gu ...
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Willer, Cristen ...
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Herrera, Blanca ...
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Jackson, Anne U
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Lim, Noha
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Scheet, Paul
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Soranzo, Nicole
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Amin, Najaf
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Aulchenko, Yurii ...
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Chambers, John C
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Drong, Alexander
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Luan, Jian'an
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Lyon, Helen N
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Rivadeneira, Fer ...
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Sanna, Serena
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Timpson, Nichola ...
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Zillikens, M Car ...
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Zhao, Jing Hua
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Almgren, Peter
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Bandinelli, Stef ...
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Bennett, Amanda ...
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Bergman, Richard ...
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Bonnycastle, Lor ...
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Bumpstead, Suzan ...
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Chanock, Stephen ...
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Cherkas, Lynn
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Chines, Peter
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Coin, Lachlan
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Cooper, Cyrus
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Crawford, Gabrie ...
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Doering, Angela
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Dominiczak, Anna
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Doney, Alex S F
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Ebrahim, Shah
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Elliott, Paul
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Erdos, Michael R
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Estrada, Karol
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Ferrucci, Luigi
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Fischer, Guido
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Forouhi, Nita G
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Gieger, Christia ...
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Grallert, Harald
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Groves, Christop ...
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Grundy, Scott
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Guiducci, Candac ...
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Hadley, David
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Hamsten, Anders
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Havulinna, Aki S
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Hofman, Albert
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Holle, Rolf
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Holloway, John W
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Illig, Thomas
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Isomaa, Bo
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Jacobs, Leonie C
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Jameson, Karen
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Jousilahti, Pekk ...
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Karpe, Fredrik
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Kuusisto, Johann ...
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Laitinen, Jaana
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Lathrop, G Mark
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Lawlor, Debbie A
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Mangino, Massimo
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McArdle, Wendy L
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Meitinger, Thoma ...
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Morken, Mario A
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Morris, Andrew P
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Munroe, Patricia
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Narisu, Narisu
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Nordström, Anna
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Nordström, Peter
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Oostra, Ben A
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Palmer, Colin N ...
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Payne, Felicity
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Peden, John F
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Prokopenko, Inga
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Renström, Frida
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Ruokonen, Aimo
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Salomaa, Veikko
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Sandhu, Manjinde ...
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Scott, Laura J
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Scuteri, Angelo
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Silander, Kaisa
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Song, Kijoung
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Yuan, Xin
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Stringham, Heath ...
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Swift, Amy J
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Tuomi, Tiinamaij ...
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Uda, Manuela
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Vollenweider, Pe ...
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Waeber, Gerard
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Wallace, Chris
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Walters, G Bragi
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Weedon, Michael ...
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Witteman, Jacque ...
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Zhang, Cuilin
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Zhang, Weihua
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Caulfield, Mark ...
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Collins, Francis ...
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Davey Smith, Geo ...
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Day, Ian N M
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Franks, Paul W
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Hattersley, Andr ...
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Hu, Frank B
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Jarvelin, Marjo- ...
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Kong, Augustine
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Kooner, Jaspal S
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Laakso, Markku
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Lakatta, Edward
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Mooser, Vincent
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Morris, Andrew D
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Peltonen, Leena
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Samani, Nilesh J
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Spector, Timothy ...
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Strachan, David ...
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Tanaka, Toshiko
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Tuomilehto, Jaak ...
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Uitterlinden, An ...
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van Duijn, Corne ...
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Wareham, Nichola ...
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Waterworth, Dawn ...
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Boehnke, Michael
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Deloukas, Panos
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Groop, Leif
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Hunter, David J
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Thorsteinsdottir ...
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Schlessinger, Da ...
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Wichmann, H-Eric ...
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Frayling, Timoth ...
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Abecasis, Gonçal ...
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Hirschhorn, Joel ...
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Loos, Ruth J F
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Stefansson, Kari
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Mohlke, Karen L
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Barroso, Inês
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McCarthy, Mark I
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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PLoS genetics
- By the university
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Umeå University
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Karolinska Institutet
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Lund University