Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

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Lindgren, Cecilia M (author)

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Article/chapterEnglish2009

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2009-06-26
Public Library of Science (PLoS),2009
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-32410
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32410URI
https://doi.org/10.1371/journal.pgen.1000508DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:119136596URI
https://lup.lub.lu.se/record/1618149URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICINE
MEDICIN

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Heid, Iris M (author)
Randall, Joshua C (author)
Lamina, Claudia (author)
Steinthorsdottir, Valgerdur (author)
Qi, Lu (author)
Speliotes, Elizabeth K (author)
Thorleifsson, Gudmar (author)
Willer, Cristen J (author)
Herrera, Blanca M (author)
Jackson, Anne U (author)
Lim, Noha (author)
Scheet, Paul (author)
Soranzo, Nicole (author)
Amin, Najaf (author)
Aulchenko, Yurii S (author)
Chambers, John C (author)
Drong, Alexander (author)
Luan, Jian'an (author)
Lyon, Helen N (author)
Rivadeneira, Fernando (author)
Sanna, Serena (author)
Timpson, Nicholas J (author)
Zillikens, M Carola (author)
Zhao, Jing Hua (author)
Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal (author)
Bandinelli, Stefania (author)
Bennett, Amanda J (author)
Bergman, Richard N (author)
Bonnycastle, Lori L (author)
Bumpstead, Suzannah J (author)
Chanock, Stephen J (author)
Cherkas, Lynn (author)
Chines, Peter (author)
Coin, Lachlan (author)
Cooper, Cyrus (author)
Crawford, Gabriel (author)
Doering, Angela (author)
Dominiczak, Anna (author)
Doney, Alex S F (author)
Ebrahim, Shah (author)
Elliott, Paul (author)
Erdos, Michael R (author)
Estrada, Karol (author)
Ferrucci, Luigi (author)
Fischer, Guido (author)
Forouhi, Nita G (author)
Gieger, Christian (author)
Grallert, Harald (author)
Groves, Christopher J (author)
Grundy, Scott (author)
Guiducci, Candace (author)
Hadley, David (author)
Hamsten, AndersKarolinska Institutet (author)
Havulinna, Aki S (author)
Hofman, Albert (author)
Holle, Rolf (author)
Holloway, John W (author)
Illig, Thomas (author)
Isomaa, Bo (author)
Jacobs, Leonie C (author)
Jameson, Karen (author)
Jousilahti, Pekka (author)
Karpe, Fredrik (author)
Kuusisto, Johanna (author)
Laitinen, Jaana (author)
Lathrop, G Mark (author)
Lawlor, Debbie A (author)
Mangino, Massimo (author)
McArdle, Wendy L (author)
Meitinger, Thomas (author)
Morken, Mario A (author)
Morris, Andrew P (author)
Munroe, Patricia (author)
Narisu, Narisu (author)
Nordström, AnnaUmeå universitet,Idrottsmedicin,Geriatrik(Swepub:umu)anagun97 (author)
Nordström, PeterUmeå universitet,Idrottsmedicin,Geriatrik(Swepub:umu)peno0014 (author)
Oostra, Ben A (author)
Palmer, Colin N A (author)
Payne, Felicity (author)
Peden, John F (author)
Prokopenko, Inga (author)
Renström, FridaUmeå universitet,Medicin(Swepub:umu)frre0001 (author)
Ruokonen, Aimo (author)
Salomaa, Veikko (author)
Sandhu, Manjinder S (author)
Scott, Laura J (author)
Scuteri, Angelo (author)
Silander, Kaisa (author)
Song, Kijoung (author)
Yuan, Xin (author)
Stringham, Heather M (author)
Swift, Amy J (author)
Tuomi, Tiinamaija (author)
Uda, Manuela (author)
Vollenweider, Peter (author)
Waeber, Gerard (author)
Wallace, Chris (author)
Walters, G Bragi (author)
Weedon, Michael N (author)
Witteman, Jacqueline C M (author)
Zhang, Cuilin (author)
Zhang, Weihua (author)
Caulfield, Mark J (author)
Collins, Francis S (author)
Davey Smith, George (author)
Day, Ian N M (author)
Franks, Paul WLund University,Lunds universitet,Umeå universitet,Medicin,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-plf (author)
Hattersley, Andrew T (author)
Hu, Frank B (author)
Jarvelin, Marjo-Riitta (author)
Kong, Augustine (author)
Kooner, Jaspal S (author)
Laakso, Markku (author)
Lakatta, Edward (author)
Mooser, Vincent (author)
Morris, Andrew D (author)
Peltonen, Leena (author)
Samani, Nilesh J (author)
Spector, Timothy D (author)
Strachan, David P (author)
Tanaka, Toshiko (author)
Tuomilehto, Jaakko (author)
Uitterlinden, André G (author)
van Duijn, Cornelia M (author)
Wareham, Nicholas J (author)
Waterworth, Dawn M (author)
Boehnke, Michael (author)
Deloukas, Panos (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Hunter, David J (author)
Thorsteinsdottir, Unnur (author)
Schlessinger, David (author)
Wichmann, H-Erich (author)
Frayling, Timothy M (author)
Abecasis, Gonçalo R (author)
Hirschhorn, Joel N (author)
Loos, Ruth J F (author)
Stefansson, Kari (author)
Mohlke, Karen L (author)
Barroso, Inês (author)
McCarthy, Mark I (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

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In:PLoS genetics: Public Library of Science (PLoS)5:6, s. e1000508-1553-7404

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By the author/editor: Lindgren, Cecili ...; Heid, Iris M; Randall, Joshua ...; Lamina, Claudia; Steinthorsdottir ...; Qi, Lu; show more...; Speliotes, Eliza ...; Thorleifsson, Gu ...; Willer, Cristen ...; Herrera, Blanca ...; Jackson, Anne U; Lim, Noha; Scheet, Paul; Soranzo, Nicole; Amin, Najaf; Aulchenko, Yurii ...; Chambers, John C; Drong, Alexander; Luan, Jian'an; Lyon, Helen N; Rivadeneira, Fer ...; Sanna, Serena; Timpson, Nichola ...; Zillikens, M Car ...; Zhao, Jing Hua; Almgren, Peter; Bandinelli, Stef ...; Bennett, Amanda ...; Bergman, Richard ...; Bonnycastle, Lor ...; Bumpstead, Suzan ...; Chanock, Stephen ...; Cherkas, Lynn; Chines, Peter; Coin, Lachlan; Cooper, Cyrus; Crawford, Gabrie ...; Doering, Angela; Dominiczak, Anna; Doney, Alex S F; Ebrahim, Shah; Elliott, Paul; Erdos, Michael R; Estrada, Karol; Ferrucci, Luigi; Fischer, Guido; Forouhi, Nita G; Gieger, Christia ...; Grallert, Harald; Groves, Christop ...; Grundy, Scott; Guiducci, Candac ...; Hadley, David; Hamsten, Anders; Havulinna, Aki S; Hofman, Albert; Holle, Rolf; Holloway, John W; Illig, Thomas; Isomaa, Bo; Jacobs, Leonie C; Jameson, Karen; Jousilahti, Pekk ...; Karpe, Fredrik; Kuusisto, Johann ...; Laitinen, Jaana; Lathrop, G Mark; Lawlor, Debbie A; Mangino, Massimo; McArdle, Wendy L; Meitinger, Thoma ...; Morken, Mario A; Morris, Andrew P; Munroe, Patricia; Narisu, Narisu; Nordström, Anna; Nordström, Peter; Oostra, Ben A; Palmer, Colin N ...; Payne, Felicity; Peden, John F; Prokopenko, Inga; Renström, Frida; Ruokonen, Aimo; Salomaa, Veikko; Sandhu, Manjinde ...; Scott, Laura J; Scuteri, Angelo; Silander, Kaisa; Song, Kijoung; Yuan, Xin; Stringham, Heath ...; Swift, Amy J; Tuomi, Tiinamaij ...; Uda, Manuela; Vollenweider, Pe ...; Waeber, Gerard; Wallace, Chris; Walters, G Bragi; Weedon, Michael ...; Witteman, Jacque ...; Zhang, Cuilin; Zhang, Weihua; Caulfield, Mark ...; Collins, Francis ...; Davey Smith, Geo ...; Day, Ian N M; Franks, Paul W; Hattersley, Andr ...; Hu, Frank B; Jarvelin, Marjo- ...; Kong, Augustine; Kooner, Jaspal S; Laakso, Markku; Lakatta, Edward; Mooser, Vincent; Morris, Andrew D; Peltonen, Leena; Samani, Nilesh J; Spector, Timothy ...; Strachan, David ...; Tanaka, Toshiko; Tuomilehto, Jaak ...; Uitterlinden, An ...; van Duijn, Corne ...; Wareham, Nichola ...; Waterworth, Dawn ...; Boehnke, Michael; Deloukas, Panos; Groop, Leif; Hunter, David J; Thorsteinsdottir ...; Schlessinger, Da ...; Wichmann, H-Eric ...; Frayling, Timoth ...; Abecasis, Gonçal ...; Hirschhorn, Joel ...; Loos, Ruth J F; Stefansson, Kari; Mohlke, Karen L; Barroso, Inês; McCarthy, Mark I; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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