Correlations between serum progesterone and smoking, and the growth fraction of cervical squamous cell carcinoma

BACKGROUND: Possible correlations between growth fraction of squamous cervical carcinomas and serum progesterone (se-P) concentrations, smoking habits and DNA ploidy were studied. MATERIALS AND METHODS: The DNA S-phase fraction (SPF), measured by flow cytometry was used as a marker of tumour growth in 103 cases of squamous cervical cancer stage IB-IV. DNA-ploidy (peridiploidy vs. aneuploidy), Se-P, se-Estradiol, smoking habits, parity, menopausal status, clinical stage and histopathological grading were compared to SPF < 14% vs. SPF > or = 14%. RESULTS: Aneuploidy, (odds ratio (OR) 10.0), se-P > or = 2.6 nmol/l (OR 7.5) and smoking (OR 3.0) were significantly associated with SPF > or = 14%, after adjustments for all factors included in the study. The association with se-P and smoking was attributed to an increased risk for the premenopausal women in the study. DISCUSSION: In this study an increased tumour growth was associated with increased leves of se-P, smoking and aneuploidy in women with invasive squamous cervical carcinoma. This study seems to experimentally confirm epidemiological studies, where smoking and long-term use of oral contraceptives have been linked to cervical neoplasms.

Backström, TKarolinska Institutet (författare)
Hellberg, DanUppsala universitet,Institutionen för kvinnors och barns hälsa (författare)
Tribukait, B (författare)
Strang, Peter,1957-Östergötlands Läns Landsting,Linköpings universitet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Hälsouniversitetet,Palliativmediicin,LAH Linnea(Swepub:liu)petst78 (författare)
Stendahl, UlfUmeå universitet,Onkologi (författare)
Umeå universitetOnkologi (creator_code:org_t)

Av författaren/redakt...: Lindström, Annik ...; Backström, T; Hellberg, Dan; Tribukait, B; Strang, Peter, 1 ...; Stendahl, Ulf

Av lärosätet: Umeå universitet; Karolinska Institutet; Uppsala universitet; Linköpings universitet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.