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Correlations betwee...
Correlations between serum progesterone and smoking, and the growth fraction of cervical squamous cell carcinoma
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- Lindström, Annika, 1953- (author)
- Umeå universitet,Onkologi
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- Backström, T (author)
- Karolinska Institutet
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- Hellberg, Dan (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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Tribukait, B (author)
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- Strang, Peter, 1957- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Hälsouniversitetet,Palliativmediicin,LAH Linnea
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- Stendahl, Ulf (author)
- Umeå universitet,Onkologi
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: Anticancer Research. - 0250-7005 .- 1791-7530. ; 20, s. 1-
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Abstract
Subject headings
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- BACKGROUND: Possible correlations between growth fraction of squamous cervical carcinomas and serum progesterone (se-P) concentrations, smoking habits and DNA ploidy were studied. MATERIALS AND METHODS: The DNA S-phase fraction (SPF), measured by flow cytometry was used as a marker of tumour growth in 103 cases of squamous cervical cancer stage IB-IV. DNA-ploidy (peridiploidy vs. aneuploidy), Se-P, se-Estradiol, smoking habits, parity, menopausal status, clinical stage and histopathological grading were compared to SPF < 14% vs. SPF > or = 14%. RESULTS: Aneuploidy, (odds ratio (OR) 10.0), se-P > or = 2.6 nmol/l (OR 7.5) and smoking (OR 3.0) were significantly associated with SPF > or = 14%, after adjustments for all factors included in the study. The association with se-P and smoking was attributed to an increased risk for the premenopausal women in the study. DISCUSSION: In this study an increased tumour growth was associated with increased leves of se-P, smoking and aneuploidy in women with invasive squamous cervical carcinoma. This study seems to experimentally confirm epidemiological studies, where smoking and long-term use of oral contraceptives have been linked to cervical neoplasms.
Keyword
- MEDICINE
- MEDICIN
- onkologi
- Oncology
Publication and Content Type
- ref (subject category)
- art (subject category)
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