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Two automatic QT al...
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Diamant, Ulla-BrittUmeå universitet,Institutionen för kirurgisk och perioperativ vetenskap,Pediatrik
(författare)
Two automatic QT algorithms compared with manual measurement in identification of long QT syndrome
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Elsevier BV,2010
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LIBRIS-ID:oai:DiVA.org:umu-32965
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32965URI
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https://doi.org/10.1016/j.jelectrocard.2009.09.008DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: Long QT syndrome (LQTS) is an inherited disorder that increases the risk of syncope and malignant ventricular arrhythmias, which may result in sudden death.METHODS: We compared manual measurement by 4 observers (QT(manual)) and 3 computerized measurements for QT interval accuracy in the diagnosis of LQTS: 1. QT measured from the vector magnitude calculated from the 3 averaged orthogonal leads X, Y, and Z (QTVCG) and classified using the same predefined QTc cut-points for classification of QT prolongation as in manual measurements; 2. QT measured by a 12-lead electrocardiogram (ECG) program (QTECG) and subsequently classified using the same cut-points as in (1) above; 3. The same QT value as in (2) above, automatically classified by a 12-lead ECG program with thresholds for QT prolongation adjusted for age and sex (QTinterpret). The population consisted of 94 genetically confirmed carriers of KCNQ1 (LQT1) and KCNH2 (LQT2) mutations and a combined control group of 28 genetically confirmed noncarriers and 66 unrelated healthy volunteers.RESULTS: QT(VCG) provided the best combination of sensitivity (89%) and specificity (90%) in diagnosing LQTS, with 0.948 as the area under the receiver operating characteristic curve. The evaluation of QT measurement by the 4 observers revealed a high interreader variability, and only 1 of 4 observers showed acceptable level of agreement in LQTS mutation carrier identification (kappa coefficient >0.75).CONCLUSION: Automatic QT measurement by the Mida1000/CoroNet system (Ortivus AB, Danderyd, Sweden) is an accurate, efficient, and easily applied method for initial screening for LQTS.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Winbo, AnnikaUmeå universitet,Pediatrik(Swepub:umu)anawio99
(författare)
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Stattin, Eva-LenaUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)evst0015
(författare)
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Rydberg, AnnikaUmeå universitet,Pediatrik(Swepub:umu)anry0014
(författare)
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Kesek, MilosUmeå universitet,Medicin(Swepub:umu)mike0005
(författare)
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Jensen, Steen MUmeå universitet,Medicin(Swepub:umu)stje0001
(författare)
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Umeå universitetInstitutionen för kirurgisk och perioperativ vetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Electrocardiology: Elsevier BV43:1, s. 25-300022-07361532-8430
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