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c-Met expression in...
c-Met expression in primary tumors and their corresponding distant metastases
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- Isaksson-Mettävainio, Martin (author)
- Umeå universitet,Patologi
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- Van Guelpen, Bethany (author)
- Umeå universitet,Patologi
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- Öberg, Åke (author)
- Umeå universitet,Patologi
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- Stenling, Roger (author)
- Umeå universitet,Patologi
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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- Henriksson, Maria L (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- Umeå : Spandidos Publications, 2009
- 2009
- English.
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In: Molecular Medicine Reports. - Umeå : Spandidos Publications. - 1791-2997. ; 1:6, s. 787-790
- Related links:
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https://www.spandido...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- c-Met is a receptor tyrosine kinase that has beenimplicated in the pathogenesis and growth of a wide variety ofhuman malignancies, including CRC, but its role in metastasisis largely unknown. We compared c-Met expression in primaryhuman colorectal carcinomas and distant metastases from thesame patients. Formalin-fixed paraffin-embedded tissuesamples from 69 colorectal cancer patients were obtained. Theprotein expression of c-Met was evaluated immunohistochemicallyusing a commercial antibody. The difference inexpression between primary tumors and their correspondingdistant metastases was analyzed using the Wilcoxon signedranktest. c-Met expression was statistically significantlylower in the distant metastases compared to their correspondingprimary tumors (p<0.001), whereas no difference was foundbetween lymph node metastases and their correspondingprimary tumors (p=0.957). The degree of c-Met expressionwas not related to clinicopathological characteristics such astumor grade and Dukes' stage at the time of primary tumordiagnosis, or to the location of the distant metastases. Wedemonstrated that c-Met expression is often reduced in distantmetastases compared to their corresponding primary colorectaltumors. Additional studies of c-Met activation and signaltransduction will increase our knowledge about the role ofc-Met in colorectal cancer metastasis.
Keyword
- c-Met
- colorectal cancer
- metastasis
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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