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Search: onr:"swepub:oai:DiVA.org:umu-33159" > The Listeria transc...

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  • Toledo-Arana, Alejandro (author)

The Listeria transcriptional landscape from saprophytism to virulence

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-05-17
  • Springer Science and Business Media LLC,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-33159
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33159URI
  • https://doi.org/10.1038/nature08080DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis. However, how this bacterium switches from a saprophyte to a pathogen is largely unknown. Here, using tiling arrays and RNAs from wild-type and mutant bacteria grown in vitro, ex vivo and in vivo, we have analysed the transcription of its entire genome. We provide the complete Listeria operon map and have uncovered far more diverse types of RNAs than expected: in addition to 50 small RNAs (<500 nucleotides), at least two of which are involved in virulence in mice, we have identified antisense RNAs covering several open-reading frames and long overlapping 5' and 3' untranslated regions. We discovered that riboswitches can act as terminators for upstream genes. When Listeria reaches the host intestinal lumen, an extensive transcriptional reshaping occurs with a SigB-mediated activation of virulence genes. In contrast, in the blood, PrfA controls transcription of virulence genes. Remarkably, several non-coding RNAs absent in the non-pathogenic species Listeria innocua exhibit the same expression patterns as the virulence genes. Together, our data unravel successive and coordinated global transcriptional changes during infection and point to previously unknown regulatory mechanisms in bacteria.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Dussurget, Olivier (author)
  • Nikitas, Georgios (author)
  • Sesto, Nina (author)
  • Guet-Revillet, Hélène (author)
  • Balestrino, Damien (author)
  • Loh, Edmund,1981-Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Johansson J(Swepub:umu)endloh03 (author)
  • Gripenland, JonasUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR),jonas.gripenland@molbiol.umu.se(Swepub:umu)josgrd01 (author)
  • Tiensuu, TeresaUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS),Johansson J(Swepub:umu)thti0002 (author)
  • Vaitkevicius, KarolisUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR),Johansson J(Swepub:umu)kasvas03 (author)
  • Barthelemy, Mathieu (author)
  • Vergassola, Massimo (author)
  • Nahori, Marie-Anne (author)
  • Soubigou, Guillaume (author)
  • Régnault, Béatrice (author)
  • Coppée, Jean-Yves (author)
  • Lecuit, Marc (author)
  • Johansson, JörgenUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR),Johansson J(Swepub:umu)jojo0001 (author)
  • Cossart, Pascale (author)
  • Umeå universitetMolekylär Infektionsmedicin, Sverige (MIMS) (creator_code:org_t)

Related titles

  • In:Nature: Springer Science and Business Media LLC459:7249, s. 950-9560028-08361476-4687

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