Oxidants and antioxidants in cardiovascular disease

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Ekblom, Kim,1970-Umeå universitet,Klinisk kemi (författare)

Oxidants and antioxidants in cardiovascular disease

BokEngelska2010

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Umeå :Umeå University,2010
86 s.
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-33762
ISBN:9789172649613
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33762URI

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Språk:engelska
Sammanfattning på:engelska

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Umeå University medical dissertations,0346-6612 ;1339

Anmärkningar

Background Cardiovascular diseases, including myocardial infarction and stroke, are the main reason of death in Sweden and Western Europe. High iron stores are believed to produce oxygen radicals, which is the presumed putative mechanism behind lipid peroxidation, atherosclerosis and subsequent cardiovascular disease. Iron levels are associated with the hemochromatosis associated HFE single nucleotide polymorphisms C282Y and H63D. Bilirubin is an antioxidant present in relatively high levels in the human body. Several previous studies have found an association between high bilirubin levels and a lower risk for cardiovascular disease. Bilirubin levels are highly influenced by the common promoter polymorphism TA-insertion UGT1A1*28, the main reason for benign hyperbilirubinemia in Caucasians. There is a lack of prospective studies on both the association of iron and bilirubin levels, and the risk for myocardial infarction and ischemic stroke. Material and methods Iron, transferrin iron saturation, TIBC, ferritin and bilirubin were analyzed and HFE C282Y, HFE H63D and UGT1A1*28 were determined in myocardial infarction and stroke cases, and their double matched referents within the Northern Sweden Health and Disease Study Cohort. Results There were no associations between iron levels in the upper normal range and risk for myocardial infarction or stroke. No associations were seen for HFE-genotypes, except for a near fivefold increase in risk for myocardial infarction in HFE H63D homozygous women. Plasma bilirubin was lower in cases vs. referents both in the myocardial infarction and the stroke cohort. Despite a strong gene-dosage effect on bilirubin levels in both cases and referents, the UGT1A1*28 polymorphism did not influence the risk for myocardial infarction or stroke. Conclusion High iron stores are not associated with increased risk for neither myocardial infarction, nor stroke. There was no association between UGT1A1*28 and the risk for myocardial infarction or stroke. Consequently data suggests that other factors, which also may lower bilirubin, are responsible for the elevated risk observed in conjunction with lower bilirubin levels.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
first-ever acute myocardial infarction
first-ever stroke
bilirubin
iron
HFE genotypes
UGT1A1*28
prospective
risk factor
Cardiovascular medicine
Kardiovaskulär medicin
Epidemiology
Epidemiologi
Clinical Chemistry
klinisk kemi

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hultdin, Johan,docentUmeå universitet,Klinisk kemi (preses)
Marklund, Stefan L,professorUmeå universitet,Klinisk kemi (preses)
Breimer, Lars,docentLaboratoriemedicinska kliniken, Universitetssjukhuset Örebro (opponent)
Umeå universitetKlinisk kemi (creator_code:org_t)

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Av författaren/redakt...: Ekblom, Kim, 197 ...; Hultdin, Johan, ...; Marklund, Stefan ...; Breimer, Lars, d ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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