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Sökning: WFRF:(Palmqvist Richard) > (2010-2014) > The role of the CpG...

  • Dahlin, Anna M,1979-Umeå universitet,Patologi (författare)

The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • 2010
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-34142
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34142URI
  • https://doi.org/10.1158/1078-0432.CCR-09-2594DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • PURPOSE: The aim of this study was to relate the CpG island methylator phenotype (CIMP; characterized by extensive promoter hypermethylation) to cancer-specific survival in colorectal cancer, taking into consideration relevant clinicopathologic factors, such as microsatellite instability (MSI) screening status and the BRAF V600E mutation. EXPERIMENTAL DESIGN: Archival tumor samples from 190 patients from the Northern Sweden Health and Disease Study (NSHDS) and 414 patients from the Colorectal Cancer in Umeå Study (CRUMS), including 574 with cancer-specific survival data, were analyzed for an eight-gene CIMP panel using quantitative real-time PCR (MethyLight). MSI screening status was assessed by immunohistochemistry. RESULTS: CIMP-low patients had a shorter cancer-specific survival compared with CIMP-negative patients (multivariate hazard ratio in NSHDS, 2.01; 95% confidence interval, 1.20-3.37; multivariate hazard ratio in CRUMS, 1.48; 95% confidence interval, 1.00-2.22). This result was similar in subgroups based on MSI screening status and was statistically significant in microsatellite stable (MSS) tumors in NSHDS. For CIMP-high patients, a shorter cancer-specific survival compared with CIMP-negative patients was observed in the MSS subgroup. Statistical significance was lost after adjusting for the BRAF mutation, but the main findings were generally unaffected. CONCLUSIONS: In this study, we found a poor prognosis in CIMP-low patients regardless of MSI screening status, and in CIMP-high patients with MSS. Although not consistently statistically significant, these results were consistent in two separate patient groups and emphasize the potential importance of CIMP and MSI status in colorectal cancer research.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001 (författare)
  • Henriksson, Maria LUmeå universitet,Patologi(Swepub:umu)mahe0061 (författare)
  • Jacobsson, Maria (författare)
  • Eklöf, VincyUmeå universitet,Patologi(Swepub:umu)viyekf03 (författare)
  • Rutegård, Jörgen,1948-Umeå universitet,Kirurgi(Swepub:umu)jaru0001 (författare)
  • Öberg, ÅkeUmeå universitet,Kirurgi (författare)
  • Van Guelpen, BethanyUmeå universitet,Patologi(Swepub:umu)beyvan99 (författare)
  • Umeå universitetPatologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Cancer Research16:6, s. 1845-18551078-04321557-3265

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