Risk of colorectal cancer seven years after flexible sigmoidoscopy screening: randomised controlled trial

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Hoff, Geir (author)

Risk of colorectal cancer seven years after flexible sigmoidoscopy screening : randomised controlled trial

Article/chapterEnglish2009

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2009-05-31
BMJ,2009
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LIBRIS-ID:oai:DiVA.org:umu-34360
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34360URI
https://doi.org/10.1136/bmj.b1846DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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OBJECTIVE: To determine the risk of colorectal cancer after screening with flexible sigmoidoscopy. DESIGN: Randomised controlled trial. SETTING: Population based screening in two areas in Norway-city of Oslo and Telemark county (urban and mixed urban and rural populations). PARTICIPANTS: 55 736 men and women aged 55-64 years. INTERVENTION: Once only flexible sigmoidoscopy screening with or without a single round of faecal occult blood testing (n=13 823) compared with no screening (n=41 913). MAIN OUTCOME MEASURES: Planned end points were cumulative incidence and mortality of colorectal cancer after 5, 10, and 15 years. This first report from the study presents cumulative incidence after 7 years of follow-up and hazard ratio for mortality after 6 years. RESULTS: No difference was found in the 7 year cumulative incidence of colorectal cancer between the screening and control groups (134.5 v 131.9 cases per 100 000 person years). In intention to screen analysis, a trend towards reduced colorectal cancer mortality was found (hazard ratio 0.73, 95% confidence interval 0.47 to 1.13, P=0.16). For attenders compared with controls, a statistically significant reduction in mortality was apparent for both total colorectal cancer (hazard ratio 0.41, 0.21 to 0.82, P=0.011) and rectosigmoidal cancer (0.24, 0.08 to 0.76, P=0.016). CONCLUSIONS: A reduction in incidence of colorectal cancer with flexible sigmoidoscopy screening could not be shown after 7 years' follow-up. Mortality from colorectal cancer was not significantly reduced in the screening group but seemed to be lower for attenders, with a reduction of 59% for any location of colorectal cancer and 76% for rectosigmoidal cancer in per protocol analysis, an analysis prone to selection bias. TRIAL REGISTRATION: Clinical trials NCT00119912.

Added entries (persons, corporate bodies, meetings, titles ...)

Grotmol, Tom (author)
Skovlund, Eva (author)
Bretthauer, Michael (author)
Schneede, JörnUmeå universitet,Klinisk farmakologi(Swepub:umu)josc0012 (author)
Umeå universitetKlinisk farmakologi (creator_code:org_t)

Related titles

In:BMJ. British Medical Journal: BMJ338, s. b1846-0959-81460959-535X
In:BMJ: BMJ338, s. b1846-0959-81381468-5833

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By the author/editor: Hoff, Geir; Grotmol, Tom; Skovlund, Eva; Bretthauer, Mich ...; Schneede, Jörn

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