Search: (WFRF:(Boshuizen Hendriek C)) pers:(Manjer Jonas) pers:(Boshuizen Hendriek C.) >
Smoking and risk fo...
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Gallo, Valentina
(author)
Smoking and risk for amyotrophic lateral sclerosis : analysis of the EPIC cohort
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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New York :J. Wiley & Sons,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-34692
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34692URI
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https://doi.org/10.1002/ana.21653DOI
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https://lup.lub.lu.se/record/1428123URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objective: Cigarette smoking has been reported as "probable" risk factor for Amyotrophic Lateral Sclerosis (ALS), a poorly understood disease in terms of aetiology. The extensive longitudinal data of the European Prospective Investigation into Cancer and Nutrition (EPIC) were used to evaluate age-specific mortality rates from ALS and the role of cigarette smoking on the risk of dying from ALS. Methods: A total of 517,890 healthy subjects were included, resulting in 4,591,325 person-years. ALS cases were ascertained through death certificates. Cox hazard models were built to investigate the role of smoking on the risk of ALS, using packs/years and smoking duration to study dose-response. Results: A total of 118 subjects died from ALS, resulting in a crude mortality rate of 2.69 per 100,000/year. Current smokers at recruitment had an almost two-fold increased risk of dying from ALS compared to never smokers (HR = 1.89, 95% C.I. 1.14-3.14), while former smokers at the time of enrollment had a 50% increased risk (HR = 1.48, 95% C.I. 0.94-2.32). The number of years spent smoking increased the risk of ALS (p for trend = 0.002). Those who smoked more than 33 years had more than a two-fold increased risk of ALS compared with never smokers (HR = 2.16, 95% C.I. 1.33-3.53). Conversely, the number of years since quitting smoking was associated with a decreased risk of ALS compared with continuing smoking. Interpretation: These results strongly support the hypothesis of a role of cigarette smoking in aetiology of ALS. We hypothesize that this could occur through lipid peroxidation via formaldehyde exposure.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Bueno-De-Mesquita, H Bas
(author)
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Vermeulen, Roel
(author)
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Andersen, Peter MUmeå universitet,Neurologi(Swepub:umu)pean0001
(author)
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Kyrozis, Andreas
(author)
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Linseisen, Jakob
(author)
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Kaaks, Rudolph
(author)
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Allen, Naomi E
(author)
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Roddam, Andrew W
(author)
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Boshuizen, Hendriek C
(author)
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Peeters, Petra H
(author)
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Palli, Domenico
(author)
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Mattiello, Amalia
(author)
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Sieri, Sabina
(author)
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Tumino, Rosario
(author)
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Jiménez-Martín, Juan-Manuel
(author)
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Díaz, María José Tormo
(author)
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Suarez, Laudina Rodriguez
(author)
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Trichopoulou, Antonia
(author)
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Agudo, Antonio
(author)
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Arriola, Larraitz
(author)
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Barricante-Gurrea, Aurelio
(author)
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Bingham, Sheila
(author)
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Khaw, Kay-Tee
(author)
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Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma
(author)
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Lindkvist, Björn
(author)
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Overvad, Kim
(author)
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Bach, Flemming W
(author)
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Tjønneland, Anne
(author)
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Olsen, Anja
(author)
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Bergmann, Manuela M
(author)
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Boeing, Heiner
(author)
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Clavel-Chapelon, Francoise
(author)
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Lund, Eiliv
(author)
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Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001
(author)
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Middleton, Lefkos
(author)
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Vineis, Paolo
(author)
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Riboli, Elio
(author)
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Umeå universitetNeurologi
(creator_code:org_t)
Related titles
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In:Annals of NeurologyNew York : J. Wiley & Sons65:4, s. 378-3850364-51341531-8249
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Gallo, Valentina
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Bueno-De-Mesquit ...
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Vermeulen, Roel
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Andersen, Peter ...
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Kyrozis, Andreas
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Linseisen, Jakob
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Kaaks, Rudolph
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Allen, Naomi E
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Roddam, Andrew W
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Boshuizen, Hendr ...
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Peeters, Petra H
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Palli, Domenico
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Mattiello, Amali ...
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Sieri, Sabina
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Tumino, Rosario
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Jiménez-Martín, ...
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Díaz, María José ...
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Suarez, Laudina ...
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Trichopoulou, An ...
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Agudo, Antonio
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Arriola, Larrait ...
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Barricante-Gurre ...
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Bingham, Sheila
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Khaw, Kay-Tee
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Manjer, Jonas
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Lindkvist, Björn
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Overvad, Kim
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Bach, Flemming W
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Tjønneland, Anne
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Olsen, Anja
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Bergmann, Manuel ...
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Boeing, Heiner
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Clavel-Chapelon, ...
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Lund, Eiliv
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Hallmans, Göran, ...
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Middleton, Lefko ...
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Vineis, Paolo
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Riboli, Elio
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