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  • Domellöf, Magnus,1963-Umeå universitet,Pediatrik (author)

Iron absorption in breast-fed infants : effects of age, iron status, iron supplements, and complementary foods.

  • Article/chapterEnglish2002

Publisher, publication year, extent ...

  • American Society for Clinical Nutrition,2002
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-35001
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35001URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Iron supplements are often recommended for older breast-fed infants, but little is known about factors affecting iron absorption from human milk or supplements. OBJECTIVE: We investigated the effects of age, iron status, and iron intake on iron absorption in healthy, term, breast-fed infants. DESIGN: Twenty-five infants were randomly assigned to receive either 1) iron supplements (1 mg x kg(-1) x d(-1)) from 4 to 9 mo of age, 2) placebo from 4 to 6 mo and iron supplements from 6 to 9 mo, or 3) placebo from 4 to 9 mo. Infants were exclusively breast-fed to 6 mo and partially breast-fed to 9 mo of age. Iron absorption was assessed by giving (58)Fe with mother's milk at 6 and 9 mo. Blood samples were obtained at 4, 6, and 9 mo, and complementary food intake was recorded at 9 mo. RESULTS: At 6 mo, mean (+/-SD) fractional iron absorption from human milk was relatively low (16.4 +/- 11.4%), with no significant difference between iron-supplemented and unsupplemented infants. At 9 mo, iron absorption from human milk remained low in iron-supplemented infants (16.9 +/- 9.3%) but was higher (P = 0.01) in unsupplemented infants (36.7 +/- 18.9%). Unexpectedly, iron absorption at 9 mo was not correlated with iron status but was significantly correlated with intake of dietary iron, including supplemental iron. CONCLUSIONS: Changes in the regulation of iron absorption between 6 and 9 mo enhance the infant's ability to adapt to a low-iron diet and provide a mechanism by which some, but not all, infants avoid iron deficiency despite low iron intakes in late infancy.

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  • Lönnerdal, Bo (author)
  • Abrams, Steven A (author)
  • Hernell, Olle,1945-Umeå universitet,Pediatrik(Swepub:umu)olhe0002 (author)
  • Umeå universitetPediatrik (creator_code:org_t)

Related titles

  • In:American Journal of Clinical Nutrition: American Society for Clinical Nutrition76:1, s. 198-2040002-91651938-3207

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Domellöf, Magnus ...
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
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Umeå University

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