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  • Andersson, YvonneUmeå universitet,Pediatrik (author)

Formula feeding skews immune cell composition toward adaptive immunity compared to breastfeeding

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • The American Association of Immunologists, Inc.2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-35060
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35060URI
  • https://doi.org/10.4049/jimmunol.0900829DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The ontogeny of the immune system and the effect thereon by type of infant feeding is incompletely understood. We analyzed frequencies and composition of immune cells in blood of breastfed (BF) and formula-fed (FF) infants at 1.5, 4, and 6 mo of age. Three formulas with the same protein concentration but with varying levels of alpha-lactalbumin and caseinoglycomacropeptide were compared. Twenty-nine exclusively BF infants served as reference, and 17 infants in each formula group completed the study. Whole blood and PBMCs were analyzed by flow cytometry and immunoflow cytometry, respectively. Leukocyte count of BF infants increased with time due to increased frequency of neutrophils. Lymphocyte count was high at 1.5 mo and was unchanged over time, as were the relative proportions of CD4+ alphabetaT cells, CD8+ alphabetaT cells, B cells, NK cells, and gammadeltaT cells. Most CD45R0+CD3+ cells were HLA-DR- and hence memory cells. Compared with breastfeeding, formula feeding resulted in a significant decrease in proportion of NK cells, but a significant increase in naive CD4+ alphabetaT cells and an elevated CD4-to-CD8 ratio, that is, 3.3 in the combined FF groups compared with 2.6 in the BF group. No significant differences were found between the three groups of FF infants. In conclusion, blood cells of lymphoid lineage did not change significantly in frequencies or composition from 1.5 to 6 mo of age in BF infants. In contrast, FF infants displayed an ongoing maturation of adaptive immunity cells and a delayed recruitment of innate immunity cells as compared with BF infants.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Hammarström, Marie-LouiseUmeå universitet,Immunologi/immunkemi,Hammarström(Swepub:umu)maha0008 (author)
  • Lönnerdal, BoDepartment of Nutrition, University of California, Davis, CA 95616 (author)
  • Graverholt, GitteArla Foods Ingredients, Aarhus, Denmark (author)
  • Fält, HelenUmeå universitet,Pediatrik (author)
  • Hernell, OlleUmeå universitet,Pediatrik(Swepub:umu)olhe0002 (author)
  • Umeå universitetPediatrik (creator_code:org_t)

Related titles

  • In:Journal of Immunology: The American Association of Immunologists, Inc.183:7, s. 4322-43280022-17671550-6606

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Andersson, Yvonn ...
Hammarström, Mar ...
Lönnerdal, Bo
Graverholt, Gitt ...
Fält, Helen
Hernell, Olle
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Pediatrics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Immunology in th ...
Articles in the publication
Journal of Immun ...
By the university
Umeå University

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