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Phylogeography of Francisella tularensis : global expansion of a highly fit clone

Vogler, Amy J (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073
Birdsell, Dawn (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073
Price, Lance B (författare)
Translational Genomics Research Institute, Phoenix, Arizona 85004
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Bowers, Jolene R (författare)
Translational Genomics Research Institute, Phoenix, Arizona 85004
Beckstrom-Sternberg, Stephen M (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073,Translational Genomics Research Institute, Phoenix, Arizona 85004
Auerbach, Raymond K (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073
Beckstrom-Sternberg, James S (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073
Johansson, Anders, 1966- (författare)
Umeå universitet,Infektionssjukdomar,Klinisk bakteriologi,Division of CBRN Defence and Security, Swedish Defence Research Agency, SE 901 82 Umeå, Sweden
Clare, Ashley (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073
Buchhagen, Jordan L (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073
Petersen, Jeannine M (författare)
Centers for Disease Control and Prevention, Fort Collins, Colorado 80521
Pearson, Talima (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073
Vaissaire, Josée (författare)
Agence Française de Sécurité Sanitaire des Aliments, Laboratoire d'Etudes et de Recherches en Pathologie Animale et Zoonoses, 94700 Maison-Alfort, France
Dempsey, Michael P (författare)
Division of Microbiology, Armed Forces Institute of Pathology, Washington, D.C. 20306
Foxall, Paul (författare)
Affymetrix, Inc., Santa Clara, California 95051 USA
Engelthaler, David M (författare)
Translational Genomics Research Institute, Phoenix, Arizona 85004
Wagner, David M (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073
Keim, Paul (författare)
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona 86011-4073,Translational Genomics Research Institute, Phoenix, Arizona 85004
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 (creator_code:org_t)
American Society for Microbiology, 2009
2009
Engelska.
Ingår i: Journal of Bacteriology. - : American Society for Microbiology. - 0021-9193 .- 1098-5530. ; 191:8, s. 2474-2484
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Francisella tularensis contains several highly pathogenic subspecies, including Francisella tularensis subsp. holarctica, whose distribution is circumpolar in the northern hemisphere. The phylogeography of these subspecies and their subclades was examined using whole-genome single nucleotide polymorphism (SNP) analysis, high-density microarray SNP genotyping, and real-time-PCR-based canonical SNP (canSNP) assays. Almost 30,000 SNPs were identified among 13 whole genomes for phylogenetic analysis. We selected 1,655 SNPs to genotype 95 isolates on a high-density microarray platform. Finally, 23 clade- and subclade-specific canSNPs were identified and used to genotype 496 isolates to establish global geographic genetic patterns. We confirm previous findings concerning the four subspecies and two Francisella tularensis subsp. tularensis subpopulations and identify additional structure within these groups. We identify 11 subclades within F. tularensis subsp. holarctica, including a new, genetically distinct subclade that appears intermediate between Japanese F. tularensis subsp. holarctica isolates and the common F. tularensis subsp. holarctica isolates associated with the radiation event (the B radiation) wherein this subspecies spread throughout the northern hemisphere. Phylogenetic analyses suggest a North American origin for this B-radiation clade and multiple dispersal events between North America and Eurasia. These findings indicate a complex transmission history for F. tularensis subsp. holarctica.

Ämnesord

NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

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