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  • Barath, StefanUmeå universitet,Lungmedicin (author)

Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-07-23
  • BioMed Central,2010
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-35381
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35381URI
  • https://doi.org/10.1186/1743-8977-7-19DOI
  • https://lup.lub.lu.se/record/1726861URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-51759URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • authorCount :15
  • BACKGROUND: Traffic emissions including diesel engine exhaust are associated with increased respiratory and cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions.OBJECTIVES: To assess the vascular and fibrinolytic effects of exposure to diesel exhaust generated during urban-cycle running conditions that mimic ambient 'real-world' exposures.METHODS: In a randomised double-blind crossover study, eighteen healthy male volunteers were exposed to diesel exhaust (approximately 250 mug/m3) or filtered air for one hour during intermittent exercise. Diesel exhaust was generated during the urban part of the standardized European Transient Cycle. Six hours post-exposure, vascular vasomotor and fibrinolytic function was assessed during venous occlusion plethysmography with intra-arterial agonist infusions.MEASUREMENTS AND MAIN RESULTS: Forearm blood flow increased in a dose-dependent manner with both endothelial-dependent (acetylcholine and bradykinin) and endothelial-independent (sodium nitroprusside and verapamil) vasodilators. Diesel exhaust exposure attenuated the vasodilatation to acetylcholine (P < 0.001), bradykinin (P < 0.05), sodium nitroprusside (P < 0.05) and verapamil (P < 0.001). In addition, the net release of tissue plasminogen activator during bradykinin infusion was impaired following diesel exhaust exposure (P < 0.05).CONCLUSION: Exposure to diesel exhaust generated under transient running conditions, as a relevant model of urban air pollution, impairs vasomotor function and endogenous fibrinolysis in a similar way as exposure to diesel exhaust generated at idling. This indicates that adverse vascular effects of diesel exhaust inhalation occur over different running conditions with varying exhaust composition and concentrations as well as physicochemical particle properties. Importantly, exposure to diesel exhaust under ETC conditions was also associated with a novel finding of impaired of calcium channel-dependent vasomotor function. This implies that certain cardiovascular endpoints seem to be related to general diesel exhaust properties, whereas the novel calcium flux-related effect may be associated with exhaust properties more specific for the ETC condition, for example a higher content of diesel soot particles along with their adsorbed organic compounds.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mills, Nicholas L (author)
  • Lundbäck, MagnusUmeå universitet,Lungmedicin (author)
  • Törnqvist, HåkanUmeå universitet,Lungmedicin (author)
  • Lucking, Andrew J (author)
  • Langrish, Jeremy P (author)
  • Söderberg, StefanUmeå universitet,Medicin,Kardiologi(Swepub:umu)stso0001 (author)
  • Boman, ChristofferUmeå universitet,Energiteknik och termisk processkemi(Swepub:umu)chrbon96 (author)
  • Westerholm, RogerStockholms universitet,Institutionen för analytisk kemi(Swepub:su)roger (author)
  • Löndahl, JakobLund University,Lunds universitet,Kärnfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Nuclear physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)desi-jlo (author)
  • Donaldson, Ken (author)
  • Mudway, Ian S (author)
  • Sandström, ThomasUmeå universitet,Lungmedicin(Swepub:umu)thsa0001 (author)
  • Newby, David E (author)
  • Blomberg, AndersUmeå universitet,Lungmedicin(Swepub:umu)anbl0001 (author)
  • Umeå universitetLungmedicin (creator_code:org_t)

Related titles

  • In:Particle and Fibre Toxicology: BioMed Central7:1, s. 19-1743-8977

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