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Metabolic syndrome ...
Metabolic syndrome and breast cancer in the me-can (metabolic syndrome and cancer) project.
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- Bjørge, Tone (author)
- Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway,Norwegian Institute of Public Health, Oslo/Bergen, Norway
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- Lukanova, Annekatrin (author)
- Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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- Jonsson, Håkan (author)
- Umeå universitet,Onkologi
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- Tretli, Steinar (author)
- Cancer Registry of Norway, Institute of Populationbased Cancer Research, Montebello, Oslo, Norway
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- Ulmer, Hanno (author)
- Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Stocks, Tanja (author)
- Umeå University,Umeå universitet,Urologi och andrologi
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- Selmer, Randi (author)
- Norwegian Institute of Public Health, Oslo/Bergen, Norway
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- Nagel, Gabriele (author)
- Institute of Empidemiology, Ulm Univesity, Ulm, Germany
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- Almquist, Martin (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Concin, Hans (author)
- Agency for Preventive and Social Medicine, Bregenz, Austria
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning
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- Häggström, Christel (author)
- Umeå universitet,Urologi och andrologi
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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- Engeland, Anders (author)
- Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway,Norwegian Institute of Public Health, Oslo/Bergen, Norway
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 19:7, s. 1737-1745
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- BACKGROUND: Few studies have assessed the metabolic syndrome (MetS) as an entity in relation to breast cancer risk, and results have been inconsistent. We aimed to examine the association between MetS factors (individually and combined) and risk of breast cancer incidence and mortality. METHODS: Two hundred ninety thousand women from Austria, Norway, and Sweden were enrolled during 1974-2005, with measurements of height, weight, blood pressure, and levels of glucose, cholesterol, and triglycerides. Relative risks (RR) of breast cancer were estimated using Cox proportional hazards regression for each MetS factor in quintiles and for standardized levels (z-scores) and for a composite z-score for the MetS. RESULTS: There were 4,862 incident cases of breast cancer and 633 deaths from breast cancer identified. In women below age 50, there was a decreased risk of incident cancer for the MetS (per 1-unit increment of z-score; RR, 0.83; 95% confidence interval, 0.76-0.90) as well as for the individual factors (except for glucose). The lowest risks were seen among the heaviest women. In women above age 60, there was an increased risk of breast cancer mortality for the MetS (RR, 1.23; 95% confidence interval, 1.04-1.45) and for blood pressure and glucose. The strongest association with mortality was seen for increased glucose concentrations. CONCLUSIONS: The MetS was associated with a decreased risk of incident breast cancer in women below age 50 with high body mass index, and with an increased risk of breast cancer mortality in women above 60. IMPACT: Lifestyle interventions as recommended for cardiovascular disease prevention may be of value to prevent breast cancer mortality in postmenopausal women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Bjørge, Tone
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Lukanova, Anneka ...
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Jonsson, Håkan
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Tretli, Steinar
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Ulmer, Hanno
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Manjer, Jonas
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Stocks, Tanja
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Selmer, Randi
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Nagel, Gabriele
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Almquist, Martin
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Concin, Hans
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Hallmans, Göran, ...
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Häggström, Chris ...
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Stattin, Pär
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Engeland, Anders
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Lund University