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A genome-wide assoc...
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Petersen, Gloria M
(author)
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-01-24
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Springer Science and Business Media LLC,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-36122
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36122URI
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https://doi.org/10.1038/ng.522DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.
Added entries (persons, corporate bodies, meetings, titles ...)
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Amundadottir, Laufey
(author)
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Fuchs, Charles S
(author)
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Kraft, Peter
(author)
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Stolzenberg-Solomon, Rachael Z
(author)
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Jacobs, Kevin B
(author)
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Arslan, Alan A
(author)
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Bueno-de-Mesquita, H Bas
(author)
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Gallinger, Steven
(author)
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Gross, Myron
(author)
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Helzlsouer, Kathy
(author)
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Holly, Elizabeth A
(author)
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Jacobs, Eric J
(author)
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Klein, Alison P
(author)
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LaCroix, Andrea
(author)
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Li, Donghui
(author)
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Mandelson, Margaret T
(author)
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Olson, Sara H
(author)
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Risch, Harvey A
(author)
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Zheng, Wei
(author)
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Albanes, Demetrius
(author)
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Bamlet, William R
(author)
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Berg, Christine D
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Buring, Julie E
(author)
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Bracci, Paige M
(author)
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Canzian, Federico
(author)
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Clipp, Sandra
(author)
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Cotterchio, Michelle
(author)
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de Andrade, Mariza
(author)
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Duell, Eric J
(author)
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Gaziano, J Michael
(author)
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Giovannucci, Edward L
(author)
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Goggins, Michael
(author)
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Hallmans, Göran,1947-Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Näringsforskning(Swepub:umu)goha0001
(author)
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Hankinson, Susan E
(author)
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Hassan, Manal
(author)
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Howard, Barbara
(author)
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Hunter, David J
(author)
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Hutchinson, Amy
(author)
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Jenab, Mazda
(author)
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Kaaks, Rudolf
(author)
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Kooperberg, Charles
(author)
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Krogh, Vittorio
(author)
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Kurtz, Robert C
(author)
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Lynch, Shannon M
(author)
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McWilliams, Robert R
(author)
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Mendelsohn, Julie B
(author)
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Michaud, Dominique S
(author)
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Parikh, Hemang
(author)
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Patel, Alpa V
(author)
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Peeters, Petra H M
(author)
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Rajkovic, Aleksandar
(author)
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Riboli, Elio
(author)
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Rodriguez, Laudina
(author)
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Seminara, Daniela
(author)
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Shu, Xiao-Ou
(author)
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Thomas, Gilles
(author)
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Tjønneland, Anne
(author)
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Tobias, Geoffrey S
(author)
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Trichopoulos, Dimitrios
(author)
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Van Den Eeden, Stephen K
(author)
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Virtamo, Jarmo
(author)
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Wactawski-Wende, Jean
(author)
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Wang, Zhaoming
(author)
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Wolpin, Brian M
(author)
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Yu, Herbert
(author)
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Yu, Kai
(author)
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Zeleniuch-Jacquotte, Anne
(author)
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Fraumeni, Joseph F
(author)
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Hoover, Robert N
(author)
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Hartge, Patricia
(author)
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Chanock, Stephen J
(author)
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Umeå universitetInstitutionen för folkhälsa och klinisk medicin
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC42:3, s. 224-2281061-40361546-1718
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Nature Genetics
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Umeå University