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Large-scale parent-...
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Nordfjäll, KatarinaUmeå universitet,Patologi
(författare)
Large-scale parent-child comparison confirms a strong paternal influence on telomere length
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2009-10-14
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Basel :Karger,2010
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-36324
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36324URI
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https://doi.org/10.1038/ejhg.2009.178DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Telomere length is documented to have a hereditary component, and both paternal and X-linked inheritance have been proposed. We investigated blood cell telomere length in 962 individuals with an age range between 0 and 102 years. Telomere length correlations were analyzed between parent-child pairs in different age groups and between grandparent-grandchild pairs. A highly significant correlation between the father's and the child's telomere length was observed (r=0.454, P<0.001), independent of the sex of the offspring (father-son: r=0.465, P<0.001; father-daughter: r=0.484, P<0.001). For mothers, the correlations were weaker (mother-child: r=0.148, P=0.098; mother-son: r=0.080, P=0.561; mother-daughter: r=0.297, P=0.013). A positive telomere length correlation was also observed for grandparent-grandchild pairs (r=0.272, P=0.013). Our findings indicate that fathers contribute significantly stronger to the telomere length of the offspring compared with mothers (P=0.012), but we cannot exclude a maternal influence on the daughter's telomeres. Interestingly, the father-child correlations diminished with increasing age (P=0.022), suggesting that nonheritable factors have an impact on telomere length dynamics during life.
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Svenson, UlrikaUmeå universitet,Patologi(Swepub:umu)ulason03
(författare)
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Norrback, Karl-FredrikUmeå universitet,Psykiatri(Swepub:umu)kaknok96
(författare)
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Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001
(författare)
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Roos, GöranUmeå universitet,Patologi(Swepub:umu)goro0001
(författare)
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Umeå universitetPatologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Human GeneticsBasel : Karger18:3, s. 385-3891018-48131476-5438
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