Sökning: L773:0197 4580 OR L773:1558 1497 >
Platelet [3H]paroxe...
Platelet [3H]paroxetine binding to 5-HT uptake sites in Alzheimer's disease.
-
Andersson, A (författare)
-
- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
-
Eriksson, K (författare)
-
visa fler...
-
Marcusson, J (författare)
-
visa färre...
-
(creator_code:org_t)
- 1991
- 1991
- Engelska.
-
Ingår i: Neurobiology of Aging. - 0197-4580 .- 1558-1497. ; 12:5, s. 531-4
- Relaterad länk:
-
https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Platelet serotonin (5-hydroxytryptamine, 5-HT) uptake sites were studied in a control group (n = 30) and an Alzheimer group (n = 40) using [3H]paroxetine as radioligand. The maximum number of binding sites (Bmax) for control (1250 +/- 60 fmol/mg protein) was not different from the Alzheimer group (1280 +/- 40 fmol/mg protein). There were no differences in apparent binding affinity (Kd): 0.046 (0.024-0.062) nM for control and 0.040 (0.027-0.061) nM for Alzheimer. Thus even though several previous studies have demonstrated marked atrophy of 5-HT containing neurites and 5-HT uptake sites in Alzheimer's disease, these findings are not found in the periphery on platelets. The platelet 5-HT uptake site cannot be used as a peripheral marker of Alzheimer's disease.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas