PCM1 and schizophrenia: a replication study in the Northern Swedish population

Moens, Lotte NUppsala universitet,Molekylär och morfologisk patologi (författare)

PCM1 and schizophrenia : a replication study in the Northern Swedish population

Previous studies implicated centrosomal dysfunction as a source of various neuropsychiatric disorders, including schizophrenia (SZ). Two recent reports [Gurling et al., 2006; Datta et al., 2008. Mol Psychiatry] described an association between polymorphisms in the PCM1 gene and SZ in a UK/Scottish population. In this study, we aimed to replicate these findings in a Northern Swedish association sample of 486 research subjects with SZ and 512 unrelated control individuals. We genotyped 12 previously described SNP markers and carried out haplotype analyses using the same multi-marker haplotypes previously reported. Though we could not replicate the association with SNPs rs445422 and rs208747, we did observe a significant protective association with intronic SNP rs13276297. Furthermore, we performed a meta-analysis comprising 1,794 SZ patients and 1,553 controls, which confirmed the previously reported association with rs445422 and rs208747. These data provide further evidence that PCM1-though certainly not a major risk factor in the Northern Swedish population-cannot be ruled out as a contributor to SZ risk and/or protection, and deserves further replication in larger populations to elucidate its role in disease etiology.

Ceulemans, ShanaApplied Molecular Genomics Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium (författare)
Alaerts, MaaikeApplied Molecular Genomics Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium (författare)
Van Den Bossche, Maarten J AApplied Molecular Genomics Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium (författare)
Lenaerts, An-SofieApplied Molecular Genomics Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium (författare)
De Zutter, SoniaApplied Molecular Genomics Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium (författare)
Norrback, Karl-FredrikUmeå universitet,Psykiatri(Swepub:umu)kaknok96 (författare)
Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001 (författare)
Del-Favero, JurgenApplied Molecular Genomics Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium (författare)
Uppsala universitetMolekylär och morfologisk patologi (creator_code:org_t)

Ingår i:American Journal of Medical Genetics: Wiley153B:6, s. 1240-12430148-72991096-8628
Ingår i:American Journal of Medical Genetics Part B: Neuropsychiatric Genetics: Wiley153B:6, s. 1240-12431552-48411552-485X

Av författaren/redakt...: Moens, Lotte N; Ceulemans, Shana; Alaerts, Maaike; Van Den Bossche, ...; Lenaerts, An-Sof ...; De Zutter, Sonia; visa fler...; Norrback, Karl-F ...; Adolfsson, Rolf; Del-Favero, Jurg ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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