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  • Lönnerholm, Gudmar,1941-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer (author)

In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Elsevier,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-37379
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37379URI
  • https://doi.org/10.1016/j.leukres.2010.09.001DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-140321URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122159176URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD <0.1% day 29. The risk of any relapse was correlated to vincristine and doxorubicin resistance, with a relative risk of 3.7 (95% CI 1.3-10.5; p=0.016) for patients resistant to both drugs. There was a significant correlation also for the subgroup with extra-medullary relapses. Our findings indicate that analysis of drug resistance can add prognostic information to other known risk-factors including MRD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Thörn, IngridUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)intho172 (author)
  • Sundström, ChristerUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)chrisund (author)
  • Frost, Britt-Marie,1955-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer(Swepub:uu)brittfro (author)
  • Flaegstad, TrondDepartmnt of Pediatrics, University and University Hospital, Tromsoe, Norway (author)
  • Heyman, MatsKarolinska Institutet (author)
  • Jonsson, Olafur GisliDepartment of Pediatrics, Landspitalinn, Reykjavik, Iceland (author)
  • Harila-Saari, ArjaDepartment of Pediatrics and Adolescence, Oulu University Hospital, Oulu, Finland (author)
  • Madsen, Hans ODepartment of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark (author)
  • Porwit, AnnaKarolinska Institutet (author)
  • Schmiegelow, KjeldPediatric Clinic II, Rigshospitalet, Copenhagen, Denmark (author)
  • Söderhäll, StefanKarolinska Institutet (author)
  • Wesenberg, FinnDepartment of Pediatrics, National Hospital, Oslo, Norway (author)
  • Vettenranta, KimDepartment of Pediatrics, University of Tampere, Finland (author)
  • Larsson, RolfUppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson(Swepub:uu)rolflars (author)
  • Forestier, ErikUmeå universitet,Pediatrik,Department of Clinical Sciences, Paediatrics, University of Umeå, Sweden(Swepub:umu)erfo0007 (author)
  • Uppsala universitetInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

Related titles

  • In:Leukemia Research: Elsevier35:4, s. 472-4780145-21261873-5835

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