Search: WFRF:(Fahlén Jessica 1973 ) >
miRNA analysis of f...
miRNA analysis of formalin-fixed squamous cell carcinomas of the tongue is affected by age of the samples
-
- Rentoft, Matilda (author)
- Umeå universitet,Patologi
-
- Fahlén, Jessica, 1973- (author)
- Umeå universitet,Statistiska institutionen
-
Coates, PJ (author)
-
show more...
-
- Laurell, Göran (author)
- Umeå universitet,Öron- näs- och halssjukdomar
-
- Sjöström, Björn (author)
- Umeå universitet,Öron- näs- och halssjukdomar
-
- Rydén, Patrik, 1969- (author)
- Umeå universitet,Institutionen för matematik och matematisk statistik,Computational Life Science Cluster (CLiC)
-
- Nylander, Karin (author)
- Umeå universitet,Patologi
-
show less...
-
(creator_code:org_t)
- Spandidos Publ. Ltd, 2011
- 2011
- English.
-
In: International Journal of Oncology. - : Spandidos Publ. Ltd. - 1019-6439 .- 1791-2423. ; 38:1, s. 61-69
- Related links:
-
https://www.spandido...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Global miRNA expression arrays were used for analysis of 836 miRNAs in formalin-fixed paraffin-embedded samples from 21 tongue cancer patients and 8 controls. Samples had been stored for one to eleven years. Results separated tumour samples from controls, however, the largest variation was correlated to sample storage time, detectable already after one year. With the use of a linear regression model we could adjust for the storage-dependent effect, leading to the identification of 54 differentially expressed miRNAs in tongue cancer, compared to 16 when using standard normalization, including up-regulation of a novel miRNA, miR-424.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- miRNA
- FFPE
- tongue carcinoma
- storage
- normalization
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database