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Bleeding patterns i...
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Ödmark, Inga-Stina,1948-
(author)
Bleeding patterns in postmenopausal women using continuous combination hormone replacement therapy with conjugated estrogen and medroxyprogesterone acetate or with 17β-estradiol and norethindrone acetate
- Article/chapterEnglish2001
Publisher, publication year, extent ...
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Elsevier BV,2001
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-3888
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3888URI
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https://doi.org/10.1067/mob.2001.112561DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1940044URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: We studied bleeding patterns in postmenopausal women who were using 2 types of continuous combination regimens. STUDY DESIGN: A prospective, double-blind, randomized study of 208 postmenopausal women treated with conjugated estrogen, 0.625 mg, and medroxyprogesterone acetate, 5 mg, or with 17beta-estradiol, 2 mg, and norethindrone acetate, 1 mg. RESULTS: The mean number of bleeding days decreased during the first 4 months of treatment (P <.002) but not thereafter. The number of bleeding days was fewer (P <.002) and the time until amenorrhea was shorter (P <.02) in patients receiving conjugated estrogen and medroxyprogesterone acetate than in patients receiving 17beta-estradiol and norethindrone acetate. The odds ratio for progression to amenorrhea with the use of conjugated estrogen and medroxyprogesterone acetate was 1.58, in comparison with the use of 17beta-estradiol and norethindrone acetate. A thick endometrium at the start of treatment resulted in more bleeding days than were found for a thin endometrium (P <.03). Body mass index, age, and blood pressure had no predictive value for bleeding problems. CONCLUSIONS: Treatment with continuous combined conjugated estrogen and medroxyprogesterone acetate resulted in fewer bleeding problems than did treatment with 17beta-estradiol and norethindrone acetate. Endometrial thickness may help to predict the chance of achieving amenorrhea during early hormone replacement therapy.
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Jonsson, BjörnUmeå universitet,Obstetrik och gynekologi
(author)
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Bäckström, TorbjörnUmeå universitet,Obstetrik och gynekologi
(author)
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Umeå universitetObstetrik och gynekologi
(creator_code:org_t)
Related titles
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In:American Journal of Obstetrics and Gynecology: Elsevier BV184:6, s. 1131-11380002-93781097-6868
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