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The effects of stor...
The effects of storage time and sampling season on the stability of serum 25-hydroxy vitamin D and androstenedione
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Agborsangaya, Calypse (författare)
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Toriola, Adetunji T (författare)
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- Grankvist, Kjell (författare)
- Umeå universitet,Klinisk kemi
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Surcel, Heljia-Marja (författare)
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Holl, Katsiaryna (författare)
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Parkkila, Seppo (författare)
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Tuohimaa, Pentti (författare)
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Lukanova, Annekatrin (författare)
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Lehtinen, Matti (författare)
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(creator_code:org_t)
- Informa UK Limited, 2010
- 2010
- Engelska.
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Ingår i: Nutrition and Cancer. - : Informa UK Limited. - 0163-5581 .- 1532-7914. ; 62:1, s. 51-57
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Knowledge of the stability of serum samples stored in large biobanks is pivotal for reliable assessment of hormone-dependent disease risks. We studied the effects of sample storage time and season of serum sampling on the stability of 25-hydroxy vitamin D (25-OHD) and androstenedione in a stratified random sample of 402 women, using paired sera from the Finnish Maternity Cohort. Serum samples selected were donated between 6 and 24 yr ago. The storage time did not affect serum 25-OHD and androstenedione levels. However, there was a significant mean difference in the 25-OHD levels of sera withdrawn during winter (first sample) vs. during summer (second sample; -18.4 nmol/l, P ≤ 0.001). Also at the individual level, there were significant differences in average 25-OHD levels between individuals with the paired sera taken at winter–winter compared with other alternatives (summer–winter, winter–summer, and summer–summer). The androstenedione levels showed no such differences. Long-term storage does not affect serum 25-OHD and androstenedione levels, but sampling season is an important determinant of 25-OHD levels. Stored serum samples can be used to study disease associations with both hormones. However, sampling season needs to be taken into account for 25-OHD by considering matching and stratification and, if possible, serial sampling.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- hormone levels; prostate-cancer; testosterone; men; androgen; women; boston; growth; risk; d-3
- Clinical chemistry
- Klinisk kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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