Search: id:"swepub:oai:DiVA.org:umu-3988" >
Loss of hyaluronan ...
-
Bertheim, UlfUmeå universitet,Institutionen för klinisk vetenskap
(author)
Loss of hyaluronan in the basement membrane zone of the skin correlates to the degree of stiff hands in diabetes patients
- Article/chapterEnglish2002
Publisher, publication year, extent ...
-
Medical Journals Sweden AB,2002
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-3988
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3988URI
-
https://doi.org/10.1080/000155502320624041DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Glycosaminoglycans are important components of all extracellular matrices. One of the glycosaminoglycans is hyaluronan, which is ubiquitously distributed throughout the connective tissue. Hyaluronan is especially abundant in the skin, in which it is of both structural and functional importance. This study describes the localization and distribution of hyaluronan in the skin of healthy individuals and of 23 patients with insulin-dependent diabetes mellitus and various degrees of limited joint mobility. In normal skin, hyaluronan staining was seen in all layers but most prominently in the papillary dermis and the basement membrane zone. In the skin from diabetic patients with normal or only moderately restricted mobility of the hands (limited joint mobility grades 0 and 1), the distribution of hyaluronan was similar to that of normal skin. In the skin of patients with severe restriction in joint mobility (limited joint mobility grade 2) the staining pattern was significantly different with weak hyaluronan staining in the papillary dermis and the basement membrane zone almost devoid of hyaluronan. Moreover, an increased epidermal thickness in the latter patients was evident as well as a pronounced hyaluronan staining compared with normal epidermis.
Subject headings and genre
-
diabetes
-
hyaluronan
-
skin
-
limited joint mobility
Added entries (persons, corporate bodies, meetings, titles ...)
-
Engström-Laurent, AnnaUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)anen0001
(author)
-
Hofer, Per-ÅkeUmeå universitet,Dermatologi och venereologi
(author)
-
Hallgren, Peter
(author)
-
Asplund, Johan
(author)
-
Hellström, StenUmeå universitet,Öron- näs- och halssjukdomar
(author)
-
Umeå universitetInstitutionen för klinisk vetenskap
(creator_code:org_t)
Related titles
-
In:Acta Dermato-Venereologica: Medical Journals Sweden AB82:5, s. 329-3340001-55551651-2057
Internet link
Find in a library
To the university's database