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- Dahlqvist, PerUmeå universitet,Institutionen för folkhälsa och klinisk medicin (author)
Environmental enrichment reverses learning impairment in the Morris water maze after focal cerebral ischemia in rats
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- 2004
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:umu-3997
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3997URI
- https://doi.org/10.1111/j.0953-816X.2004.03248.xDOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Cognitive impairment is common after ischemic stroke. In rodent stroke models using occlusion of the middle cerebral artery (MCA) this is reflected by impaired spatial memory associated with the size of the ischemic lesion. Housing in an enriched environment enhances brain plasticity and improves recovery of sensorimotor functions after experimental stroke in rats. In this study we report that postischemic housing in an enriched environment also attenuates the long-term spatial memory impairment after MCA occlusion and extinguishes the association between spatial memory and infarct volume. An enriched environment did not significantly alter the expression of selected neuronal plasticity-associated genes 1 month after MCA occlusion, indicating that most of the adaptive changes induced by an enriched environment have already occurred at this time point. We conclude that the attenuated memory impairment induced by environmental enrichment after MCA occlusion provides a useful model for further studies on the neurobiological mechanisms of recovery of cognitive functions after ischemic stroke.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- animals
- brain ischemia/metabolism/*psychology
- cognition/physiology
- environment
- male
- maze learning/*physiology
- memory disorders/metabolism/prevention & control/*psychology
- rats
- sprague-dawley
- synapsins/biosynthesis
- Internal medicine
- Invärtesmedicin
Added entries (persons, corporate bodies, meetings, titles ...)
- Rönnbäck, AnnicaUmeå universitet,Institutionen för folkhälsa och klinisk medicin (author)
- Bergström, Sven-AndersUmeå universitet,Institutionen för folkhälsa och klinisk medicin (author)
- Söderström, IngegerdUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)inso0001 (author)
- Olsson, TommyUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)tool0003 (author)
- Umeå universitetInstitutionen för folkhälsa och klinisk medicin (creator_code:org_t)
Related titles
- In:European Journal of Neuroscience19:8, s. 2288-22980953-816X1460-9568
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