Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk

We identified six highly correlated SNPs that show strong and comparable associations with risk of type 2 diabetes, but further refinement of these associations will require large sample sizes (>100,000) or studies in ethnically diverse populations. Low frequency variants in WFS1 are unlikely to have a large impact on type 2 diabetes risk in white U.K. populations, highlighting the complexities of undertaking association studies with low-frequency variants identified by resequencing.

Wheeler, Eleanor (author)
Morris, Andrew P (author)
Ricketts, Sally L (author)
Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005 (author)
Daly, Allan (author)
Wasson, Jon (author)
Permutt, Alan (author)
Hattersley, Andrew T (author)
Glaser, Benjamin (author)
Franks, Paul WUmeå universitet,Medicin(Swepub:umu)pafr0003 (author)
McCarthy, Mark I (author)
Wareham, Nicholas J (author)
Sandhu, Manjinder S (author)
Barroso, Inês (author)
Umeå universitetNäringsforskning (creator_code:org_t)

By the author/editor: Fawcett, Katheri ...; Wheeler, Eleanor; Morris, Andrew P; Ricketts, Sally ...; Hallmans, Göran, ...; Rolandsson, Olov; show more...; Daly, Allan; Wasson, Jon; Permutt, Alan; Hattersley, Andr ...; Glaser, Benjamin; Franks, Paul W; McCarthy, Mark I; Wareham, Nichola ...; Sandhu, Manjinde ...; Barroso, Inês; show less...

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