SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Dzhambazov Balik)
 

Sökning: WFRF:(Dzhambazov Balik) > Design of glycopept...

  • Andersson, Ida E,1982-Umeå universitet,Kemiska institutionen (författare)

Design of glycopeptides used to investigate class II MHC binding and T-Cell responses associated with autoimmune arthritis

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • 2011-03-15
  • Public Library of Science,2011
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-41050
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-41050URI
  • https://doi.org/10.1371/journal.pone.0017881DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122247909URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Vid avhandlingens utgivning manuskript med annan titel: "Design of glycopeptide chemical probes used to investigate multiresponses associated with autoimmune arthritis"
  • The glycopeptide fragment CII259–273 from type II collagen (CII) binds to the murine Aq and human DR4 class II Major Histocompatibility Complex (MHC II) proteins, which are associated with development of murine collagen-induced arthritis (CIA) and rheumatoid arthritis (RA), respectively. It has been shown that CII259–273 can be used in therapeutic vaccination of CIA. This glycopeptide also elicits responses from T-cells obtained from RA patients, which indicates that it has an important role in RA as well. We now present a methodology for studies of (glyco)peptide-receptor interactions based on a combination of structure-based virtual screening, ligand-based statistical molecular design and biological evaluations. This methodology included the design of a CII259–273 glycopeptide library in which two anchor positions crucial for binding in pockets of Aq and DR4 were varied. Synthesis and biological evaluation of the designed glycopeptides provided novel structure-activity relationship (SAR) understanding of binding to Aq and DR4. Glycopeptides that retained high affinities for these MHC II proteins and induced strong responses in panels of T-cell hybridomas were also identified. An analysis of all the responses revealed groups of glycopeptides with different response patterns that are of high interest for vaccination studies in CIA. Moreover, the SAR understanding obtained in this study provides a platform for the design of second-generation glycopeptides with tuned MHC affinities and T-cell responses.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Andersson, C David,1978-Umeå universitet,Kemiska institutionen(Swepub:umu)dadaon01 (författare)
  • Batsalova, TsvetelinaMedicinal Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm (författare)
  • Dzhambazov, BalikMedicinal Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm (författare)
  • Holmdahl, RikardKarolinska Institutet (författare)
  • Kihlberg, Jan,1957-Umeå universitet,Kemiska institutionen,AstraZeneca R&D Mölndal, Mölndal, Sweden(Swepub:umu)jaki0001 (författare)
  • Linusson, Anna,1970-AstraZeneca R&D Mölndal, Mölndal(Swepub:umu)analin99 (författare)
  • Umeå universitetKemiska institutionen (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLOS ONE: Public Library of Science6:3, s. e17881-1932-6203

Internetlänk

Hitta via bibliotek

  • PLOS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy