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Regulation by SIRPα...
Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues
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- Saito, Yasuyuki (author)
- Gunma University, Gunma University Graduate School of Medicine
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- Iwamura, Hiroko (author)
- Gunma University
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- Kaneko, Tetsuya (author)
- Gunma University
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- Ohnishi, Hiroshi (author)
- Gunma University
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- Murata, Yoji (author)
- Gunma University
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- Okazawa, Hideki (author)
- Gunma University
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- Kanazawa, Yoshitake (author)
- Gunma University
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- Sato-Hashimoto, Miho (author)
- Gunma University
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- Kobayashi, Hisae (author)
- Gunma University
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- Oldenborg, Per-Arne (author)
- Umeå universitet,Histologi med cellbiologi
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- Naito, Makoto (author)
- Niigata University Graduate School of Medical and Dental Sciences
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- Kaneko, Yoriaki (author)
- Gunma University Graduate School of Medicine
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- Nojima, Yoshihisa (author)
- Gunma University Graduate School of Medicine
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- Matozaki, Takashi (author)
- Gunma University, Kobe University Graduate School of Medicine
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(creator_code:org_t)
- American Society of Hematology, 2010
- 2010
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 116:18, s. 3517-3525
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The molecular basis for regulation of dendritic cell (DC) development and homeostasis remains unclear. Signal regulatory protein α (SIRPα), an immunoglobulin superfamily protein that is predominantly expressed in DCs, mediates cell-cell signaling by interacting with CD47, another immunoglobulin superfamily protein. We now show that the number of CD11c(high) DCs (conventional DCs, or cDCs), in particular, that of CD8-CD4+ (CD4+) cDCs, is selectively reduced in secondary lymphoid tissues of mice expressing a mutant form of SIRPα that lacks the cytoplasmic region. We also found that SIRPα is required intrinsically within cDCs or DC precursors for the homeostasis of splenic CD4+ cDCs. Differentiation of bone marrow cells from SIRPα mutant mice into DCs induced by either macrophage-granulocyte colony-stimulating factor or Flt3 ligand in vitro was not impaired. Although the accumulation of the immediate precursors of cDCs in the spleen was also not impaired, the half-life of newly generated splenic CD4+ cDCs was markedly reduced in SIRPα mutant mice. Both hematopoietic and nonhematopoietic CD47 was found to be required for the homeostasis of CD4+ cDCs and CD8-CD4- (double negative) cDCs in the spleen. SIRPα as well as its ligand, CD47, are thus important for the homeostasis of CD4+ cDCs or double negative cDCs in lymphoid tissues.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Publication and Content Type
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- art (subject category)
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Blood
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- By the author/editor
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Saito, Yasuyuki
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Iwamura, Hiroko
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Kaneko, Tetsuya
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Ohnishi, Hiroshi
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Murata, Yoji
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Okazawa, Hideki
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Kanazawa, Yoshit ...
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Sato-Hashimoto, ...
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Kobayashi, Hisae
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Oldenborg, Per-A ...
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Naito, Makoto
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Kaneko, Yoriaki
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Nojima, Yoshihis ...
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Matozaki, Takash ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Blood
- By the university
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Umeå University