Search: id:"swepub:oai:DiVA.org:umu-41355" >
Stress-evoked tyros...
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Ohnishi, HiroshiGunma University
(author)
Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test
- Article/chapterEnglish2010
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-41355
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-41355URI
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https://doi.org/10.1523/JNEUROSCI.0257-10.2010DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Severe stress induces changes in neuronal function that are implicated in stress-related disorders such as depression. The molecular mechanisms underlying the response of the brain to stress remain primarily unknown, however. Signal regulatory protein alpha (SIRPalpha) is an Ig-superfamily protein that undergoes tyrosine phosphorylation and binds the protein tyrosine phosphatase Shp2. Here we show that mice expressing a form of SIRPalpha that lacks most of the cytoplasmic region manifest prolonged immobility (depression-like behavior) in the forced swim (FS) test. FS stress induced marked tyrosine phosphorylation of SIRPalpha in the brain of wild-type mice through activation of Src family kinases. The SIRPalpha ligand CD47 was important for such SIRPalpha phosphorylation, and CD47-deficient mice also manifested prolonged immobility in the FS test. Moreover, FS stress-induced tyrosine phosphorylation of both the NR2B subunit of the NMDA subtype of glutamate receptor and the K+-channel subunit Kvbeta2 was regulated by SIRPalpha. Thus, tyrosine phosphorylation of SIRPalpha is important for regulation of depression-like behavior in the response of the brain to stress.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Murata, TakaakiGunma University, Gunma University Graduate School of Medicine
(author)
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Kusakari, ShinyaGunma University
(author)
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Hayashi, YurikoGunma University
(author)
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Takao, KeizoKyoto University Graduate School of Medicine, Fujita Health University
(author)
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Maruyama, ToshiGunma University
(author)
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Ago, YukioOsaka University
(author)
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Koda, Ken
(author)
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Jin, Feng-JieGunma University
(author)
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Okawa, KatsuyaKyowa Hakko Kirin Company Ltd., Takasaki
(author)
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Oldenborg, Per-ArneUmeå universitet,Histologi med cellbiologi(Swepub:umu)peol0001
(author)
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Okazawa, HidekiGunma University
(author)
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Murata, YojiGunma University
(author)
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Furuya, NobuhikoGunma University Graduate School of Medicine
(author)
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Matsuda, Toshio
(author)
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Miyakawa, TsuyoshiKyoto University Graduate School of Medicine, Fujita Health University
(author)
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Matozaki, TakashiGunma University, Kobe University Graduate School of Medicine
(author)
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Gunma UniversityGunma University, Gunma University Graduate School of Medicine
(creator_code:org_t)
Related titles
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In:Journal of Neuroscience30:31, s. 10472-104830270-64741529-2401
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- By the author/editor
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Ohnishi, Hiroshi
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Murata, Takaaki
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Kusakari, Shinya
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Hayashi, Yuriko
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Takao, Keizo
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Maruyama, Toshi
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Ago, Yukio
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Koda, Ken
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Jin, Feng-Jie
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Okawa, Katsuya
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Oldenborg, Per-A ...
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Okazawa, Hideki
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Murata, Yoji
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Furuya, Nobuhiko
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Matsuda, Toshio
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Miyakawa, Tsuyos ...
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Matozaki, Takash ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Journal of Neuro ...
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Umeå University