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Tumor necrosis fact...
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Dossus, LaureDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk : the EPIC study
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-03-08
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Geneve :International union against cancer,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-41629
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-41629URI
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https://doi.org/10.1002/ijc.25840DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-α (TNF-α), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-α and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-α (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, Ptrend = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, Ptrend = 0.07) and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, Ptrend = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-α and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Becker, SusenDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Rinaldi, SabinaSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
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Lukanova, AnnekatrinDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Tjønneland, AnneInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
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Olsen, AnjaInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
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Overvad, KimDepartment of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark
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Chabbert-Buffet, NathalieDepartment of Obstetrics and Gynecology, APHP Hospital Tenon and UMPC, Paris, France
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Boutron-Ruault, Marie-ChristineINSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France
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Clavel-Chapelon, FrançoiseINSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France
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Teucher, BirgitDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Chang-Claude, JennyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Pischon, TobiasDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
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Boeing, HeinerDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
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Trichopoulou, AntoniaDepartment of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
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Benetou, VasilikiDepartment of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
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Valanou, ElisavetDepartment of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
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Palli, DomenicoMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy
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Sieri, SabinaDepartment of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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Tumino, RosarioCancer Registry and Histopathology Unit, “Civile – M.P. Arezzo” Hospital, Ragusa, Italy
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Sacerdote, CarlottaCenter for Cancer Prevention (CPO Piedmont), Turin, Italy
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Galasso, RoccoInstituto di Ricovero e Cura a Carattere Scientifico (IRCCS-CROOB), Rionero in Vulture (PZ), Italy
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Redondo, Maria-LuísaPublic Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain
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Bonet Bonet, CatalinaUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain
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Molina-Montes, EstherAndalusian School of Public Health, Granada, Spain
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Altzibar, Jone MCIBER de Epidemiología y Salud Pública (CIBERESP), Spain
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Chirlaque, Maria-DoloresCIBER de Epidemiología y Salud Pública (CIBERESP), Spain
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Ardanaz, EvaCIBER de Epidemiología y Salud Pública (CIBERESP), Spain
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Bueno-de-Mesquita, H BasCIBER de Epidemiología y Salud Pública (CIBERESP), Spain
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van Duijnhoven, Fränzel J BNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
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Peeters, Petra H MJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
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Onland-Moret, N CharlotteJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
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Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001
(author)
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Idahl, AnnikaUmeå universitet,Obstetrik och gynekologi,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)anid0002
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Khaw, Kay-TeeDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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Wareham, NicholasMRC Epidemiology Unit, Cambridge, United Kingdom
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Allen, NaomiNuffield Department of Clinical Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
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Romieu, IsabelleInternational Agency for Research on Cancer, Lyon, France
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Fedirko, VeronikaInternational Agency for Research on Cancer, Lyon, France
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Hainaut, PierreDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
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Romaguera, DoraDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
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Norat, TeresaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
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Riboli, ElioDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
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Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, GermanySection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
(creator_code:org_t)
Related titles
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In:International Journal of CancerGeneve : International union against cancer129:8, s. 2032-20370020-71361097-0215
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Dossus, Laure
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Becker, Susen
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Rinaldi, Sabina
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Lukanova, Anneka ...
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Tjønneland, Anne
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Olsen, Anja
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Overvad, Kim
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Chabbert-Buffet, ...
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Teucher, Birgit
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Chang-Claude, Je ...
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Pischon, Tobias
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Boeing, Heiner
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Trichopoulou, An ...
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Benetou, Vasilik ...
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Valanou, Elisave ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Sacerdote, Carlo ...
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Galasso, Rocco
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Redondo, Maria-L ...
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Bonet Bonet, Cat ...
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Molina-Montes, E ...
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Altzibar, Jone M
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Chirlaque, Maria ...
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Ardanaz, Eva
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Bueno-de-Mesquit ...
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van Duijnhoven, ...
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Peeters, Petra H ...
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Onland-Moret, N ...
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Lundin, Eva
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Idahl, Annika
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Allen, Naomi
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Romieu, Isabelle
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Fedirko, Veronik ...
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Hainaut, Pierre
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Romaguera, Dora
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Norat, Teresa
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Riboli, Elio
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Kaaks, Rudolf
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