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Variation in the Cd...
Variation in the Cd3 zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes.
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- Lundholm, Marie (author)
- Umeå universitet,Patologi
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- Mayans, Sofia (author)
- Umeå universitet,Medicinsk och klinisk genetik,Univ Copenhagen, Dept Dis Biol, Fac Life Sci, DK-1870 Copenhagen C, Denmark
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- Motta, Vinicius (author)
- Umeå universitet,Medicinsk och klinisk genetik,Univ Toronto, Dept Immunol, Toronto, ON, Canada
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- Löfgren-Burström, Anna (author)
- Umeå universitet,Patologi
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- Danska, Jayne (author)
- Univ Toronto, Dept Immunol, Toronto, ON, Canada
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- Holmberg, Dan (author)
- Umeå universitet,Medicinsk och klinisk genetik,Univ Copenhagen, Dept Dis Biol, Fac Life Sci, DK-1870 Copenhagen C, Denmark
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(creator_code:org_t)
- 2010-05-15
- 2010
- English.
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In: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 184:10, s. 5537-5544
- Related links:
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http://www.jimmunol....
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Subject headings
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- Tuning of TCR-mediated activation was demonstrated to be critical for lineage fate in T cell development, as well as in the control of autoimmunity. In this study, we identify a novel diabetes susceptibility gene, Idd28, in the NOD mouse and provide evidence that Cd3zeta (Cd247) constitutes a prime candidate gene for this locus. Moreover, we show that the allele of the Cd3zeta gene expressed in NOD and DBA/2 mouse strains confers lower levels of T cell activation compared with the allele expressed by C57BL/6 (B6), BALB/c, and C3H/HeJ mice. These results support a model in which the development of autoimmune diabetes is dependent on a TCR signal mediated by a less-efficient NOD allele of the Cd3zeta gene.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- medicin
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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