WFRF:(Feng Gu)
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- Gu, Qiang (author)
VKORC1-1639G>A, CYP2C9, EPHX1691A>G genotype, body weight, and age are important predictors for warfarin maintenance doses in patients with mechanical heart valve prostheses in southwest China
- Article/chapterEnglish2010
Publisher, publication year, extent ...
- 2010-09-15
- Springer Science and Business Media LLC,2010
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-42279
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42279URI
- https://doi.org/10.1007/s00228-010-0863-9DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- There were great interindividual differences in warfarin maintenance dosage (ranging from 0.6 to 8.4 mg/day) among the 127 patients with mechanical heart valve prostheses. VKORC1-1639G>A, CYP2C9, EPHX1691A>G polymorphism, body weight, and age were found to affect the dose demands. Multiple linear regression models incorporating genetic polymorphisms of VKORC1, CYP2C9, EPHX1691A>G, and the nongenetic factors of age and body weight were developed, and explained up to 76.8% of the total variation (adjusted R (2) of 0.743) in warfarin maintenance doses in southwest Chinese patients with mechanical heart valve prostheses.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
- Gene polymorphism
- Warfarin therapy
- SNP
- CYP2C9
- VKORC1-1639G>A
- EPHX1691A>G
- Southwest Han Chinese patients
- Mechanical heart valve prostheses
- Clinical chemistry
- Klinisk kemi
- Clinical Chemistry
- klinisk kemi
Added entries (persons, corporate bodies, meetings, titles ...)
- Kong, Yan (author)
- Schneede, JörnUmeå universitet,Klinisk kemi,Klinisk farmakologi(Swepub:umu)josc0012 (author)
- Xiao, Ying-Bin (author)
- Chen, Lin (author)
- Zhong, Qian-Jin (author)
- Wang, Xue-Feng (author)
- Hao, Jia (author)
- Chen, Bai-Cheng (author)
- Chen, Jing-Jin (author)
- Umeå universitetKlinisk kemi (creator_code:org_t)
Related titles
- In:European Journal of Clinical Pharmacology: Springer Science and Business Media LLC66:12, s. 1217-12270031-69701432-1041
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- Wang, Xue-Feng
- Hao, Jia
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- Chen, Jing-Jin
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